Evidence map›Paper›PMID 40705233›Full record

ArticleProbiotics and antimicrobial proteins2026

Alleviative Effect of Vaginal Lactobacilli with Probiotic Potential from Healthy Chinese Women on Bacterial Vaginosis Caused by Gardnerella vaginalis in Mice.

Congcong Li, Yimin Cheng, Tingting Zong, Shuqi Guo, Hongli Zhu, Penggao Dai, Chao Chen, Huijuan Wang

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Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Congcong Li *National Engineering Research Center for Miniaturized Detection Systems, College of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
Yimin Cheng *Department of Obstetrics and Gynecology, Hospital of Xi'an Shiyou University, Xi'an, Shaanxi, China.
Tingting ZongProvincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi'an, Shaanxi, China.
Shuqi GuoNational Engineering Research Center for Miniaturized Detection Systems, College of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
Hongli ZhuNational Engineering Research Center for Miniaturized Detection Systems, College of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
Penggao DaiNational Engineering Research Center for Miniaturized Detection Systems, College of Life Sciences, Northwest University, Xi'an, Shaanxi, China.
Chao ChenNational Engineering Research Center for Miniaturized Detection Systems, College of Life Sciences, Northwest University, Xi'an, Shaanxi, China. cchen898@nwu.edu.cn.
Huijuan WangNational Engineering Research Center for Miniaturized Detection Systems, College of Life Sciences, Northwest University, Xi'an, Shaanxi, China. whj@nwu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The main treatment strategy for bacterial vaginosis (BV) is antibiotic therapy, but they are not effective in restoring the vaginal microecology, which can lead to recurrence. This study aimed to isolate the dominant lactobacilli strains from the vagina of healthy Chinese women, evaluate their potential probiotic properties and explore their alleviative effect on BV infected mice. Our study isolated 43 strains of vaginal-dominant Lactobacillus. Four strains of Lactobacillus. crispatus, four strains of Lactobacillus. gasseri, and two strains of Lactobacillus. jensenii showed strong inhibitory effects on Gardnerella vaginalis and were safe in vitro. Subsequently, through principal component analysis on seven functional indicators of these 10 strains, Lact. crispatus G-7, Lact. gasseri B-5, and Lact. jensenii M-1 ranked the top beneficial strains and were finally selected as the candidate therapeutic strain for in vivo experiments. Animal experiments showed that Lact. crispatus G-7 was superior to other Lactobacillus species and the positive control metronidazole in restoring vaginal health (pH and H

Indexed as

Gardnerella vaginalisLactobacillusProbioticsVaginaVaginosis, BacterialAdultAnimalsChinaCytokinesEast Asian PeopleFemaleHumansMiceCytokinesBacterial vaginosisLactobacillus Gardnerella·vaginalisProbiotic propertiesVaginal microbiota

Identifiers

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.