ArticleNeuroscience bulletin2026
Single-Nucleus Transcriptomic Sequencing Revealed Cellular and Molecular Changes in a Pilocarpine-Induced Epilepsy Rat Model.
Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Single-nucleus transcriptomics reveals cell type-specific remodeling and epilepsy-associated microglia.iScience · 2026Article
- SnRNA-seq reveals seizure-induced remodelling of excitatory and inhibitory neuron populations.Scientific reports · 2026Article
- Spatiotemporal transcriptomic mapping reveals region-specific glial activation and astrocyte shifts in epileptogenesis beyond the hippocampus.Acta neuropathologica communications · 2026Article
- Teneurin-2 and related proteins in reactive astrocytes afterFrontiers in neuroscience · 2025Article
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Authors and funding
6 authors.
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Abstract
Uncovering the underlying process of epileptogenesis is crucial for developing effective treatment strategies for epilepsy. However, the cellular and molecular changes throughout epileptogenesis are not fully understood. In this study, single-nucleus RNA sequencing was performed on the hippocampus, temporal cortex, and thalamus across the acute, latent, and chronic phases in a pilocarpine-induced rat model and controls. We created a comprehensive single-nucleus transcriptomic atlas of rat epileptogenesis, consisting of 311,177 single nuclei. Our analysis revealed distinct transcriptional signatures across the three phases and regions, including significant gene expression changes in the acute phase and critical synaptic and neural network remodeling in the thalamus during the latent phase. Notably, we identified two novel astrocyte clusters during epileptogenesis, with the EX-Astro C3-IN pathway emerging as a potential intervention target. The dataset provides a detailed understanding of the dynamic cellular and molecular landscape of epileptogenesis.
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