Evidence map›Paper›PMID 40705214›Full record

ArticleMolecular diversity2026

Design, synthesis and antifungal evaluation of perillaldehyde derivatives as potential laccase inhibitors.

Zhennan Cui, Yiming Zheng, Ning Ou, Ziyan Zhang, Boyu Lv, Jia Li, Wen Gu

Abstract read
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In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhennan CuiJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, China.
Yiming ZhengJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, China.
Ning OuJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, China.
Ziyan ZhangJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, China.
Boyu LvJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, China.
Jia LiSchool of Foreign Languages, Nanjing Xiaozhuang University, Nanjing, 211171, China. lika_li19890409@163.com.
Wen GuJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, Jiangsu Provincial Key Lab for the Chemistry and Utilization of Agro-forest Biomass, Jiangsu Key Lab of Biomass-Based Green Fuels and Chemicals, College of Chemical Engineering, Nanjing Forestry University, Nanjing, 210037, China. njguwen@163.com.

Funding

National Natural Science Foundation of China 32471810
6 · The paper itself

Abstract

The development of novel fungicides has still been a hot topic in the field of pesticide research. In this study, three series of new perillaldehyde hydrazide, amide and acylthiourea derivatives (3a-3n, 4a-4f, and 6a-6f) were designed and synthesized. The in vitro antifungal activity of the title compounds against seven plant pathogens was evaluated. The results displayed that several hydrazide derivatives showed significant antifungal activity. Especially, compound 3b exhibited the most potent inhibitory activity against Monilinia fructicola (EC

Indexed as

Antifungal AgentsDrug DesignEnzyme InhibitorsLaccaseAscomycotaMicrobial Sensitivity TestsMolecular Docking SimulationMonoterpenesPyrusStructure-Activity RelationshipAntifungal AgentsEnzyme InhibitorsLaccaseMonoterpenesperillaldehydeAntifungal activityLaccase inhibitorMechanism studyPerillaldehyde derivativesSynthesis

Identifiers

PMID40705214

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.