Evidence map›Paper›PMID 40705181›Full record

ReviewMedical oncology (Northwood, London, England)2025

Metabolic reprogramming and functional crosstalk within the tumor microenvironment (TME) and A Multi-omics anticancer approach.

Rashid Mir, Jamsheed Javid, Mohammad Fahad Ullah, Salma Alrdahe, Ibrahim Abdullah Altedlawi, Syed Khalid Mustafa, Mohammed M Jalal, Malik A Altayar, Aziz Dhaher Albalawi, Muhammed Kamal Abunab and 5 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medical oncology (Northwood, London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Rashid MirDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Prince Fahad Bin Sultan Chair for Biomedical Research, University of Tabuk, Tabuk, Saudi Arabia. rashid@ut.edu.sa.
Jamsheed JavidDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Prince Fahad Bin Sultan Chair for Biomedical Research, University of Tabuk, Tabuk, Saudi Arabia.
Mohammad Fahad UllahDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Prince Fahad Bin Sultan Chair for Biomedical Research, University of Tabuk, Tabuk, Saudi Arabia.
Salma AlrdaheDepartment of Biology, Faculty of Science, University of Tabuk, 47512, Tabuk, Saudi Arabia.
Ibrahim Abdullah AltedlawiDepartment of Surgical Oncology, Faculty of Medicine, University of Tabuk, 47512, Tabuk, Saudi Arabia.
Syed Khalid MustafaDepartment of Chemistry, Faculty of Sciences, University of Tabuk, 47512, Tabuk, Saudi Arabia.
Mohammed M JalalDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Prince Fahad Bin Sultan Chair for Biomedical Research, University of Tabuk, Tabuk, Saudi Arabia.
Malik A AltayarDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Prince Fahad Bin Sultan Chair for Biomedical Research, University of Tabuk, Tabuk, Saudi Arabia.
Aziz Dhaher AlbalawiKing Khaled Hospital, MOH, Tabuk and Department of Medical Laboratory Technology, FAMS, University of Tabuk, Tabuk, Saudi Arabia.
Muhammed Kamal AbunabKing Khaled Hospital, MOH, Tabuk and Department of Medical Laboratory Technology, FAMS, University of Tabuk, Tabuk, Saudi Arabia.
Hanadi Saud AlanaziKing Khaled Hospital, MOH, Tabuk and Department of Medical Laboratory Technology, FAMS, University of Tabuk, Tabuk, Saudi Arabia.
Jameel BarnawiDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Prince Fahad Bin Sultan Chair for Biomedical Research, University of Tabuk, Tabuk, Saudi Arabia.
Naseh A Algehainy
Faisal H AltemaniDepartment of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Prince Fahad Bin Sultan Chair for Biomedical Research, University of Tabuk, Tabuk, Saudi Arabia.
Faris J Tayeb

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumors are characterized by a complex interplay of various cell types, each contributing to the unique metabolic landscape of the tumor microenvironment (TME). The key metabolic interactions explored within the TME include nutrient competition, symbiotic nutrient exchange, and the role of metabolites as signaling messengers. Metabolic flexibility allows cancer cells to survive and proliferate even under harsh conditions, such as hypoxia and nutrient deprivation. Recent advances highlight that tumors possess inherent metabolic heterogeneity, underpinning the intricate web of intra- and extra- tumoral metabolic connections. Harnessing the power of multi-omics approaches offers unprecedented insights into this metabolic diversity, paving the way for innovative therapeutic strategies targeting the metabolic crosstalk within the tumor microenvironment. Multi-omics approaches, integrating genomics, transcriptomics, proteomics, and metabolomics data, provide a comprehensive view of tumor metabolism. This holistic approach allows for the identification of key metabolic pathways and regulatory networks that drive tumor progression, as well as potential vulnerabilities that can be exploited for therapeutic intervention. In this review, we discuss the metabolic symphony within the TME, the intricacies of tumor metabolism through multi-omics methodologies, and the prospects of devising innovative and effective cancer therapeutic strategies.

Indexed as

MetabolomicsNeoplasmsTumor MicroenvironmentAnimalsGenomicsHumansMetabolic Networks and PathwaysMetabolic ReprogrammingMultiomicsProteomicsCancerCancer therapeutic strategiesMetabolic reprogrammingMulti-omicsTumor metabolismTumor microenvironment

Identifiers

PMID40705181

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.