ArticleJapanese journal of radiology2025
Contribution of white matter microstructure to diffusion tensor image analysis along perivascular space in obstructive sleep apnea.
Article in Japanese journal of radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Glymphatic system dysfunction in central nervous system malignancies: A narrative review.Neurosurgical review · 2026Review
- Diffusion tensor image analysis along the perivascular space (DTI-ALPS): redefining its interpretation and role.Japanese journal of radiology · 2026Review
- Editorial for "MRI Diffusion Tensor Image Analysis Along the Perivascular Space: Effects of Mean Tract Orientation Divergence".Journal of magnetic resonance imaging : JMRI · 2026Article
- Beyond FLAIR: PRISM (polarity-preserving real inversion solute mapping)-a new Frontier in real inversion recovery MRI for intracranial and sensory organ fluid assessment.Japanese journal of radiology · 2026Review
- Modifiable Physiological Factors Associated With Human Glymphatic and Interstitial Fluid Dynamics-Related Measures: A Scoping Review.The European journal of neuroscience · 2026Article
- In reply.Japanese journal of radiology · 2026Article
- White matter microstructural alterations in obstructive sleep apnea assessed by time-dependent diffusion MRI.Japanese journal of radiology · 2026Article
- Glymphatic Dysfunction, Brain Damage, and Clinical Disability in Spinocerebellar Ataxia Type 3.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Associations of Cognitive Impairment with Putative Glymphatic-Related Imaging Indices and Cortical Atrophy in Cerebral Amyloid Angiopathy.Biomedicines · 2026Article
- Putative glymphatic dysfunction links extracellular fluid dysregulation to white matter degeneration and clinical impairment in amyotrophic lateral sclerosis.BMC medicine · 2026Article
- Perivascular fluid clearance links choroid plexus changes to cognitive performance in cerebral small vessel disease.Brain informatics · 2026Article
- Automatic determination of glymphatic flow with the DTI-ALPS-index along the principal axis system in native imaging space corrects for head and fiber orientation.Magnetic resonance in medicine · 2026Article
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Authors and funding
16 authors.
Funding
Abstract
purposeWe aimed to evaluate whether the ALPS index derived from diffusion tensor image analysis along the perivascular space (DTI-ALPS) is influenced by white matter fibres within the analysis region, particularly commissural fibres from the corpus callosum that traverse this area in psychiatric patients with suspected obstructive sleep apnea (OSA). We also investigated associations between diffusion-based parameters, sleep-related data, and neurofluid-related imaging metrics.
methodsFifty participants with OSA underwent brain magnetic resonance imaging and polysomnography, including diffusion tensor and structural sequences. Among them, 8 participants had no psychiatric comorbidities, while the remaining 42 had various psychiatric disorders in addition to OSA. Diffusion-based parameters were obtained, and both the original and variant ALPS index were calculated. Correlation analyses were conducted with sleep-related data and neurofluid-related imaging parameters, including choroid plexus volume (CPV) and volume of white matter lesion burden (WMHV). Mediation analyses were also performed to explore the influence of white matter diffusivity on the perivascular diffusivity index.
resultsThe ALPS index showed weak to moderate correlations with multiple sleep-related variables. It also correlated with CPV and WMHV. Mediation analyses demonstrated that diffusivity within white matter fibres was associated with the ALPS index. Moreover, variant ALPS indices measured in the corpus callosum may reflect fluid motion in the direction of perivascular spaces.
conclusionThese findings suggest that the ALPS index is influenced by both diffusivity along perivascular spaces and white matter microstructure, particularly commissural fibres. Although it should not be regarded as a highly specific marker of perivascular space function, variant indices support partial perivascular contribution. Furthermore, associations with sleep and neurofluid-related metrics imply that white matter architecture and inter-fibre spaces may serve as plausible routes for interstitial fluid flow.
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