ArticleMedical oncology (Northwood, London, England)2025
ROCK inhibition suppresses glioblastoma via a PTEN-associated reduction in PI3K/AKT signaling.
Article in Medical oncology (Northwood, London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
3 authors.
Funding
Abstract
Glioblastoma is the most common primary malignant brain tumor. It is aimed to elucidate the role of ROCK in the regulation of PI3K signaling inhibited by PTEN and to evaluate the effects of ROCK inhibitors Thiazovivin and GSK 429286 on glioblastoma as a new therapeutic strategy. U87 MG and L929 cell lines were used to research the cytotoxic effect of ROCK inhibitors Thiazovivin and GSK 429286. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method and xCELLigence real-time cell analyzer were used to determine its effect on cell viability. To assess the impact of ROCK inhibitors on PTEN protein levels, PTEN expression in cell lysates was quantitatively determined in vitro using the PTEN ELISA Kit. Total protein concentration was measured using the BCA protein assay kit, p-Akt and PTEN protein level was determined by the western blot method. Showed that GSK 429286 and Thiazovivin significantly reduced U87 MG cell viability even at low concentrations. When IC
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