ArticleJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2025
An LC-MS/MS-based approach for monitoring monoaminergic status in lizard brains: method development and real-samples application.
Article in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Monoamines play essential roles in regulating brain functions, influencing behaviours and physiological processes. Despite significant advances in mammalian models, studies on reptiles are limited, restricting our understanding of their neurochemical and behavioural interactions. This study aimed to develop and validate a selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous quantification of 11 monoamines and their metabolites (adrenaline, dopamine, levodopa, homovanillic acid, 5-hydroxyindoleacetic acid, 5-hydroxytryptophan, serotonin, norepinephrine, tryptophan, tyrosine, vanillylmandelic acid) in lizard brains, examining interspecies and sex-specific variations and their potential link to behavioural differences between Podarcis siculus and Podarcis melisellensis. Brain samples from 132 lizards were analysed using the optimized LC-MS/MS method, which included rigorous pre-analytical preparation to ensure analyte stability. The method demonstrated high sensitivity and specificity for monoamines, with the limit of quantitation lower than 5 ng mL
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