Evidence map›Paper›PMID 40705095›Full record

ArticleMolecular biology reports2025

Ponicidin attenuates Aβ

Cuihong Wang, Linzhao Wang, Xiaoqing Liu, Jiping Wang, Min Chen, Jiao Li

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Cuihong Wang *Department of Pharmacy, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, 1500 Zhouyuan Road, Pudong New District, Shanghai, 201318, P.R. China.
Linzhao Wang *Department of Pharmacy, The Affiliated Hospital of Qingdao Binhai University, Qingdao, 266071, Shandong, P.R. China.
Xiaoqing LiuDepartment of Pharmacy, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, 1500 Zhouyuan Road, Pudong New District, Shanghai, 201318, P.R. China.
Jiping WangDepartment of Pharmacy, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, 1500 Zhouyuan Road, Pudong New District, Shanghai, 201318, P.R. China.
Min ChenDepartment of Pharmacy, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, 1500 Zhouyuan Road, Pudong New District, Shanghai, 201318, P.R. China. zply_89@163.com.
Jiao LiInstitute of Biomaterials and Biomedicine, School of Food and Pharmacy, Shanghai Zhongqiao Vocational and Technical University, No. 3888 Caolang Road, Jinshan District, Shanghai, 201514, P.R. China. lijiao_2012@126.com.

Funding

The Scientific Research Program of Shanghai Pudong New Area Health Commission (the Youth Program) PW2022B-04the scientific research project of Shanghai Zhongqiao Vocational and Technical University ZQZR202427
6 · The paper itself

Abstract

backgroundAlzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amyloid-beta (Aβ) accumulation that leads to synaptic dysfunction and neuronal death. Ponicidin, a natural diterpenoid, possesses anti-inflammatory and neuroprotective properties. However, its potential effects on Aβ-induced neurotoxicity remain unclear. This study investigated whether ponicidin ameliorates Aβ

methodsHT22 cells were exposed to Aβ

resultsPonicidin significantly attenuated Aβ

conclusionThese findings suggest that ponicidin exerts neuroprotective effects against Aβ

Indexed as

Amyloid beta-PeptidesDiterpenesHippocampusPeptide FragmentsSirtuin 1Alzheimer DiseaseAnimalsApoptosisCell LineCell SurvivalMiceNeuronsNeuroprotective AgentsOxidative StressPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktAmyloid beta-Peptidesamyloid beta-protein (1-42)DiterpenesNeuroprotective AgentsPeptide FragmentsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSirt1 protein, mouseSirtuin 1Alzheimer’s diseaseAβ1−42Hippocampal neuronsNeuroprotectionPI3K/AktPonicidinSIRT1

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.