ArticleInternational urogynecology journal2025
Genome-Wide Associations with Urinary Incontinence in Women: Case-Control Study.
Article in International urogynecology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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Who cites it
1 citing paper in PubMed.
- Genome-wide association meta-analyses over one million individuals identify 54 loci associated with urinary incontinence and its subtypes.medRxiv : the preprint server for health sciences · 2026Article
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Authors and funding
4 authors.
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Abstract
introduction and hypothesisThe objective was to determine the genetic variants associated with urinary incontinence subtypes using genome-wide association studies (GWAS).
methodsWe conducted a case-control study of women older than 18 with available genetic data and at least one International Classification of Diseases 10 urinary (stress, urge or mixed) incontinence diagnosis between May 2008 and May 2023. Controls had available genetic data with no urinary incontinence diagnosis. Demographic, health, and genomic data were obtained from our institution's electronic medical records and Biobank. Quality control measures applied to the raw data excluded variants with call rate < 95%, with Hardy-Weinberg equilibrium exact p value < 1 × 10
resultsThe first GWAS run had 4270 cases with 5 single-nucleotide polymorphisms (SNPs) significantly associated with mixed and 3 SNPs significantly associated with urgency incontinence (p < 5 × 10
conclusionOur study proposes possible new genetic associations in women diagnosed with mixed and stress urinary incontinence that should be validated across other studies.
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