ArticleThe Journal of antimicrobial chemotherapy2025
Comparing the mortality of patients with sepsis using empirical piperacillin/tazobactam and cefepime: analysis of the MIMIC-IV database.
Article in The Journal of antimicrobial chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectivesWe compared the effectiveness of piperacillin/tazobactam and cefepime as empirical antibiotics for sepsis. PATIENTS AND
methodsThis retrospective cohort study included adult patients diagnosed with sepsis, receiving either piperacillin/tazobactam or cefepime as empirical treatment. Relevant data were extracted from the Medical Information Mart for Intensive Care IV database. Stabilized inverse probability of treatment weighting was used to adjust for the imbalance in covariates between both groups. The primary outcome was 90-day mortality, and Clostridium difficile infection and vancomycin-resistant enterococci colonization rates were the secondary outcomes.
resultsAmong 2485 eligible patients, 1161 received piperacillin/tazobactam and 1324 received cefepime as empirical treatment for sepsis. After stabilized inverse probability of treatment weighting, 90-day mortality did not significantly differ between the groups. The Kaplan-Meier curve showed no difference in 90-day mortality between the two groups (log-rank test, P = 0.947). Similarly, the rate of C. difficile infection and vancomycin-resistant enterococci colonization did not significantly differ.
conclusionsNo significant difference was observed in the risk of mortality in the empirical use of either antibiotic, suggesting comparable efficacy in sepsis. Therefore, individual patient characteristics should be considered when treating sepsis rather than systematically recommending antibiotics.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.