Evidence map›Paper›PMID 40705007›Full record

ArticleeLife2025

Coordinated

Ozanna Burnicka-Turek, Katy A Trampel, Brigitte Laforest, Michael T Broman, Xinan H Yang, Zoheb Khan, Eric Rytkin, Binjie Li, Ella Schaffer, Margaret Gadek and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. International journal of molecular sciences · 2026
    Article
  3. Genetic loci responsible for atrioventricular block in children.Frontiers in cell and developmental biology · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Ozanna Burnicka-TurekDepartments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, United States.ORCID https://orcid.org/0000-0002-3770-4314
Katy A TrampelDepartments of Biomedical Engineering, Northwestern University, Chicago, United States.ORCID https://orcid.org/0000-0001-5735-1037
Brigitte LaforestDepartments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, United States.ORCID https://orcid.org/0000-0001-6919-8922
Michael T BromanDepartment of Medicine, Section of Cardiology, University of Chicago, Chicago, United States.
Xinan H YangDepartments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, United States.
Zoheb KhanDepartments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, United States.
Eric RytkinDepartments of Biomedical Engineering, Northwestern University, Chicago, United States.
Binjie LiDepartments of Biomedical Engineering, Northwestern University, Chicago, United States.
Ella SchafferDepartments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, United States.
Margaret GadekDepartments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, United States.
Kaitlyn M ShenDepartments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, United States.
Igor R EfimovDepartments of Biomedical Engineering, Northwestern University, Chicago, United States.ORCID https://orcid.org/0000-0002-1483-5039
Ivan P MoskowitzDepartments of Pediatrics, Pathology, and Human Genetics, University of Chicago, Chicago, United States.ORCID https://orcid.org/0000-0003-0014-4963

Funding

Discovery and interrogation of genetic regulatory variation impacting Atrial Fibrillation riskR01HL163523 · NHLBI · UNIVERSITY OF CHICAGO · PI HE, XIN, MOSKOWITZ, IVAN PAUL · 2022 to 2025
$3.1M
Gene Regulatory Non-Coding RNAs in the Human HeartR01HL148719 · NHLBI · UNIVERSITY OF CHICAGO · PI MOSKOWITZ, IVAN PAUL, RUTHENBURG, ALEXANDER JACKSON · 2019 to 2022
$2.3M
American Heart Association 13POST17290028NHLBI NIH HHS R01 HL148719NHLBI NIH HHS R01 HL163523NIH HHS R01 HL148719NIH HHS R01 HL163523
6 · The paper itself

Abstract

The cardiac conduction system (CCS) orchestrates the electrical impulses that enable coordinated contraction of the cardiac chambers. The T-box transcription factors

Indexed as

Gene Expression RegulationHeart Conduction SystemHeart VentriclesT-Box Domain ProteinsTranscription, GeneticAnimalsMiceMice, KnockoutMyocytes, CardiacT-Box Domain ProteinsT-box transcription factor 5Tbx3 protein, mousearrhythmiacardiac conduction system (CCS)developmental biologygeneticsgenomicsheart rhythmmousereprogramming of VCST-box transcriptional factorsTbx3Tbx3:Tbx5-deficient miceTbx3:Tbx5 double-conditional mouse lineTbx5ventricular conduction system (VCS)

Identifiers

PMID40705007
PMCPMC12289313

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.