Evidence map›Paper›PMID 40704996›Full record

ArticleeLife2025

Contraction-induced endocardial

Shuo Chen, Jinxiu Liang, Jie Yin, Weijia Zhang, Peijun Jiang, Wenyuan Wang, Xiaoying Chen, Yuanhong Zhou, Peng Xia, Fan Yang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Elucidating Gene Functions in Congenital Heart Disease.Current treatment options in cardiovascular medicine · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shuo Chen *Department of Cardiology, Center for Genetic Medicine, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.ORCID https://orcid.org/0009-0005-5058-028X
Jinxiu Liang *Department of Cardiology, Center for Genetic Medicine, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Jie YinDepartment of Cardiology, Center for Genetic Medicine, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.ORCID https://orcid.org/0000-0002-1166-2443
Weijia ZhangDepartment of Cardiology, Center for Genetic Medicine, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Peijun JiangDepartment of Cardiology, Center for Genetic Medicine, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Wenyuan WangTaiKang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, China.
Xiaoying ChenDepartment of Biophysics, and Kidney Disease Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Yuanhong ZhouZhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China.
Peng XiaZhejiang Provincial Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China.
Fan YangDepartment of Biophysics, and Kidney Disease Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Ying GuDepartment of Cardiology, Center for Genetic Medicine, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.
Ruilin ZhangTaiKang Medical School (School of Basic Medical Sciences), Wuhan University, Wuhan, China.ORCID https://orcid.org/0000-0002-6594-450X
Peidong HanDepartment of Cardiology, Center for Genetic Medicine, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, China.ORCID https://orcid.org/0000-0002-6717-4000

Funding

National Key Research and Development Program of China 2023YFA1800600National Natural Science Foundation of China 31871462National Natural Science Foundation of China 32170823National Natural Science Foundation of China 92468104
6 · The paper itself

Abstract

Biomechanical cues play an essential role in sculpting organ formation. Comprehending how cardiac cells perceive and respond to biomechanical forces is a biological process with significant medical implications that remains poorly understood. Here, we show that biomechanical forces activate endocardial

Indexed as

EndocardiumHeart ValvesInhibitor of Differentiation Protein 2Myocardial ContractionZebrafishZebrafish ProteinsAnimalsGene Expression Regulation, DevelopmentalInhibitor of Differentiation Protein 2Zebrafish Proteinscontractiondevelopmental biologyheartid2bvalvezebrafish

Identifiers

PMID40704996
PMCPMC12289310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.