Evidence map›Paper›PMID 40704610›Full record

Trial reportClinical and translational science2025

A Multicenter Randomized Controlled Study on Pharmacokinetic-Guided Vancomycin Use in Children With Severe Infections.

Fuxiang He, Ya Yang, Bo Zhou, Chengcheng Li, Yu Feng, Xuexin Wang, Haifeng Liu, Yuhang Hu, Hongmin Fu, Yingbo Zou and 6 more

Abstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical and translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Fuxiang HeDepartment of Emergency Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.ORCID 0009-0008-8491-1966
Ya YangKunming Children's Hospital, Kunming, China.
Bo ZhouDepartment of Pharmacy, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.
Chengcheng LiZunyi First People's Hospital, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Yu FengChengdu Women and Children's Central Hospital, Chengdu, China.
Xuexin WangGuiyang Maternal and Child Health Care Hospital, Guiyang, Guizhou, China.
Haifeng LiuKunming Children's Hospital, Kunming, China.
Yuhang HuSichuan Maternal and Child Health Care Hospital, Sichuan Women and Children's Hospital, Chengdu, China.
Hongmin FuKunming Children's Hospital, Kunming, China.
Yingbo ZouZunyi First People's Hospital, The Third Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Guoying ZhangChengdu Women and Children's Central Hospital, Chengdu, China.
Jianli ChenGuiyang Maternal and Child Health Care Hospital, Guiyang, Guizhou, China.
Yueqiang FuDepartment of Critical Care Unit, Children's Hospital Affiliated to Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.
Shufang XiaoKunming Children's Hospital, Kunming, China.
Lan HuDepartment of Critical Care Unit, Children's Hospital Affiliated to Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.
Chengjun LiuDepartment of Critical Care Unit, Children's Hospital Affiliated to Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study is a multicenter, randomized controlled prospective trial aimed at evaluating the effects of two vancomycin pharmacokinetics/pharmacodynamics (PK/PD) parameters on clinical outcomes in children with different severe infections: trough concentration (C

Indexed as

Anti-Bacterial AgentsVancomycinAdolescentArea Under CurveChildChild, PreschoolChinaDrug MonitoringFemaleHumansInfantIntensive Care Units, PediatricMaleMicrobial Sensitivity TestsProspective StudiesSeverity of Illness IndexAnti-Bacterial AgentsVancomycinage groupsclinical efficacyinfectionspediatricspharmacokineticsvancomycin

Identifiers

PMID40704610
PMCPMC12287809

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.