Evidence map›Paper›PMID 40704599›Full record

ArticleOral diseases2026

From Dysplasia to Carcinoma: Expression Patterns of Dermokine, Matriptase, and Tryptase in OPMD.

Lara Maria Alencar Ramos Innocentini, Mateus Gonçalves Miranda, Carol Kobori da Fonseca, Pedro Franco Ferreira, Leandro Dorigan de Macedo, Graziela Cavalcanti, Luiz Carlos Conti de Freitas, Ana Carolina Fragoso Motta, Alan Grupioni Lourenço, Katiuchia Uzzun Sales

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Oral diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Lara Maria Alencar Ramos InnocentiniDepartment of Stomatology, Public Health and Forensic Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Mateus Gonçalves MirandaDepartment of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirao Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.ORCID https://orcid.org/0000-0002-5971-3844
Carol Kobori da FonsecaDepartment of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirao Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.
Pedro Franco FerreiraDepartment of Stomatology, Public Health and Forensic Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Leandro Dorigan de MacedoDentistry and Stomatology Division, Department of Ophthalmology, Otolaryngology, Head and Neck Surgery, Ribeirão Preto Clinical Hospital, Ribeirão Preto School of Medicine, São Paulo University, Ribeirão Preto, SP, Brazil.ORCID https://orcid.org/0000-0001-9708-5845
Graziela CavalcantiDepartment of Ophthalmology, Otolaryngology, Head and Neck Surgery, Ribeirão Preto Clinical Hospital, Ribeirão Preto School of Medicine, São Paulo University, Ribeirão Preto, SP, Brazil.
Luiz Carlos Conti de FreitasDepartment of Ophthalmology, Otolaryngology, Head and Neck Surgery, Ribeirão Preto Clinical Hospital, Ribeirão Preto School of Medicine, São Paulo University, Ribeirão Preto, SP, Brazil.
Ana Carolina Fragoso MottaDepartment of Stomatology, Public Health and Forensic Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.ORCID https://orcid.org/0000-0002-3887-9239
Alan Grupioni LourençoDepartment of Basic and Oral Biology, Ribeirão Preto School of Dentistry, University of São Paulo, Ribeirão Preto, SP, Brazil.
Katiuchia Uzzun SalesDepartment of Cell and Molecular Biology and Pathogenic Bioagents, Ribeirao Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 400039/2014-1Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação de Amparo à Pesquisa do Estado de São Paulo 2011/00711-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2011/07853-3Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/14597-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2024/10667-7Laboratório Nacional de Biociências
6 · The paper itself

Abstract

backgroundThe malignant transformation of oral potentially malignant disorders (OPMDs) lacks reliable molecular markers. Dermokine and matriptase are involved in epithelial differentiation and inflammation, while tryptase is associated with the tumor microenvironment, which may contribute to carcinogenesis. This study investigated these molecules as potential biomarkers for predicting the malignant progression of OPMDs.

methodsThis was a cross-sectional comparative study. Paired normal oral mucosa (NM) and OPMD tissues (n = 21) were assessed, while oral and oropharyngeal squamous cell carcinoma (OOSCC) samples (n = 64) were evaluated using tissue microarrays. Proteomic analysis of five OPMD cases identified dermokine, tryptase, and matriptase as potential biomarkers, further examined through clinical, histopathological, and immunohistochemical analyses across NM, OPMD, and OOSCC tissues.

resultsFemales comprised 52% of the OPMD group, whereas males accounted for 87.5% of OOSCC cases. Dermokine, tryptase, and matriptase showed higher expression in OPMD and OOSCC than NM. Dermokine was predominantly observed in OPMD, well-differentiated OOSCC, and NM from patients who progressed to malignancy (p = 0.019). Matriptase expression shifted from membranous in NM to diffuse in OPMD and OOSCC, similarly to tryptase.

conclusionDermokine may represent an early marker of transformation, while altered matriptase patterns could help differentiate dysplasia from carcinoma.

Indexed as

Carcinoma, Squamous CellCell Transformation, NeoplasticCytokinesMouth NeoplasmsPrecancerous ConditionsSerine EndopeptidasesTryptasesAdultAgedBiomarkers, TumorCross-Sectional StudiesDisease ProgressionFemaleHumansMaleMiddle AgedBiomarkers, TumorCytokinesmatriptaseSerine EndopeptidasesTryptasesdermokinematriptaseoral dysplasiaoral squamous cell carcinomaserine proteasestryptase

Identifiers

PMID40704599
PMCPMC13031407

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.