Evidence map›Paper›PMID 40704584›Full record

ArticleEquine veterinary journal2026

Endoscopically assessed mucus parameters in equine asthma: Relationship to clinical history and cytological findings data.

Julia Drespling, Leonie Berwanger, Heike Kühn, Bianca Schwarz, Marcus Doherr, Lars Mundhenk

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Article in Equine veterinary journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Julia DresplingInstitute of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.
Leonie BerwangerInstitute of Veterinary Epidemiology and Biostatistics, Freie Universität Berlin, Berlin, Germany.ORCID https://orcid.org/0009-0007-5112-7422
Heike KühnEquiZyt UG Laboratory, Steinhöring, Germany.
Bianca SchwarzEquiZyt UG Laboratory, Steinhöring, Germany.
Marcus DoherrInstitute of Veterinary Epidemiology and Biostatistics, Freie Universität Berlin, Berlin, Germany.
Lars MundhenkInstitute of Veterinary Pathology, Freie Universität Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-9033-9360

Funding

Deutsche Forschungsgemeinschaft MU 3015/3-1
6 · The paper itself

Abstract

backgroundMucus parameters are hallmark diagnostic features of equine asthma (EA).

objectivesTo investigate the relationship between mucus quantity score and mucus viscosity score with signalment, history, clinical findings and cytological parameters. STUDY

designRetrospective cross-sectional study.

methodsMucus quantity and viscosity scores, signalment, history and clinical findings recorded for diagnostic purposes from up to 1599 samples, and cytological values of the corresponding bronchoalveolar lavage fluid (BALF) and tracheobronchial secretions were analysed. The cut-off value of a mucus quantity score >2 for the diagnosis of mild to moderate EA (MEA) was used to calculate the odds ratios for MEA and severe EA (SEA). Associations were tested via a multivariate Kruskal-Wallis test. The mucus scores were analysed pairwise with cytological characteristics, anamnestic data and clinical signs by testing for independence using the chi-square test. Correlations were evaluated using the non-parametric Spearman's rank correlation coefficient.

resultsA mucus quantity score >2 was associated with increased odds of diagnosing SEA (odds ratio 3.6, 95% confidence interval 1.75, 7.17, p < 0.001), but not for MEA. A weak positive correlation was found between neutrophil granulocytes in BALF and mucus quantity score (rho: 0.353, p < 0.001) as well as mucus viscosity score (rho: 0.225, p < 0.001). The mucus scores for quantity and viscosity were significantly associated (p < 0.001) with age, respiratory rate and arterial oxygen partial pressure values, and significantly associated (p < 0.001) with season, type of nasal discharge and respiratory pattern. However, no associations were found with body condition score (BCS), sex and breed. MAIN LIMITATIONS: This was a convenience sample with a cytologically unremarkable control group, but no healthy control group.

conclusionsMucus quantity score is a diagnostic parameter for the diagnosis of SEA. Associations between mucus scores and neutrophilic influx and with some clinical parameters were identified, while there was no confirmed relationship to BCS.

Indexed as

AsthmaEndoscopyHorse DiseasesMucusAnimalsBronchoalveolar Lavage FluidCross-Sectional StudiesFemaleHorsesMaleRetrospective StudiesViscositybronchoalveoläre lavageflüssigkeitbronchoalveolar lavage fluidhorsemucus quantitymucus scoringpferdrespiratorische zytologierespiratory cytologyschleimbeurteilungschleim mengetracheobronachiale sekretetracheobronchial secretions

Identifiers

PMID40704584
PMCPMC13041601

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