Evidence map›Paper›PMID 40704402›Full record

ArticleChembiochem : a European journal of chemical biology2025

Quantification of Small Molecule Partitioning in a Biomolecular Condensate with 2D Nuclear Magnetic Resonance Spectroscopy.

Julie Maibøll Buhl, Sujata Mahapatra, Magnus Kjærgaard, Frans A A Mulder

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Julie Maibøll BuhlInterdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wieds Vej 14, Aarhus C, 8000, Denmark.ORCID https://orcid.org/0009-0007-5706-723X
Sujata MahapatraDepartment of Molecular Biology and Genetics, Aarhus University, Universitetsbyen 81, Aarhus C, 8000, Denmark.
Magnus KjærgaardInterdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wieds Vej 14, Aarhus C, 8000, Denmark.ORCID https://orcid.org/0000-0002-7020-9366
Frans A A MulderInterdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wieds Vej 14, Aarhus C, 8000, Denmark.ORCID https://orcid.org/0000-0001-9427-8406

Funding

Danish Agency for Science and Higher Education AU- 2010-612-181Novo Nordisk Fonden NNF20OC0063808Villum Fonden 27963
6 · The paper itself

Abstract

Several intrinsically disordered proteins have been shown to undergo phase separation into a dense and dilute phase and this process is intimately linked with the regulation of cellular processes. It is therefore highly relevant to know how metabolites partition between these phases. It is shown here that the partitioning of components in a complex mixture can be robustly obtained from a single set of 2D nuclear magnetic resonance (NMR) spectra recorded on the dilute and dense phases separately using "time-zero extrapolated" heteronuclear single quantum coherence (HSQC

Indexed as

Biomolecular CondensatesComplex MixturesMagnetic Resonance SpectroscopyCresolsCyclic AMPDioxanesGuanidineHydrophobic and Hydrophilic InteractionsPhase Separationtert-Butyl Alcohol1,4-dioxane4-cresolComplex MixturesCresolsCyclic AMPDioxanesGuanidinetert-Butyl Alcoholcondensateliquid–liquid phase separationmetabolitenuclear magnetic resonancepartitioning

Identifiers

PMID40704402
PMCPMC12442244

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.