ArticleChembiochem : a European journal of chemical biology2025
Stereoselective Synthesis of Cannabidiol and its Unnatural Enantiomer to Evaluate Anxiolytic-Like Properties and Memory Interactions.
Article in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Unveiling the Origin of Regioselectivity in Iron(III)-Promoted Friedel-Crafts Synthesis of Cannabinoids: Theoretical Studies and Synthetic Applications.The Journal of organic chemistry · 2026Article
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5 authors.
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Abstract
(-)-Cannabidiol (CBD) is a nonpsychotropic phytocannabinoid found in Cannabis strains with well-established pharmacological applications. Conversely, (+)-cannabidiol (ent-CBD), the non-natural enantiomer of CBD, has been involved in a limited number of pharmacological studies. Therefore, CBD and ent-CBD are synthesized using (R)-(-)- and (S)-(+)-carvone as starting materials, respectively, via a highly diastereoselective 10-camphorsulfonic acid (CSA) catalyzed Friedel-Crafts reaction as the key step. Pharmacological studies are conducted using the plus-maze discriminative avoidance task (PM-DAT) to evaluate the interaction between memory and anxiety-like behavior as well as spontaneous motor activity in both young adult and aged male mice. The results show that ent-CBD at a dose of 20 mg kg
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