Association of Body Mass Index and Exhaled Breath Nitric Oxide: A Cross-Sectional Analysis of Shahedieh Cohort Study.

Seyyed Jalil Mirmohammadi, Alireza Dehghan Dehnavi, Mahmood Vakili, Mohammad Hossein Davari, Amir Houshang Mehrparvar, Mohammad Javad Zare Sakhvidi

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Article in Tanaffos, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Seyyed Jalil MirmohammadiIndustrial Diseases Research Center, Department of Occupational Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Alireza Dehghan DehnaviDepartment of Occupational Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Mahmood VakiliHealth Monitoring Research Center, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Mohammad Hossein DavariDepartment of Occupational Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Amir Houshang MehrparvarIndustrial Diseases Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Mohammad Javad Zare SakhvidiDepartment of Occupational Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

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6 · The paper itself

Abstract

Background: Fractional exhaled nitric oxide is a method of assessing inflammation in the airway and its level may affected by some factors such as age, gender, and body mass index. This study was performed to assess the relationship between "Body Mass Index" (BMI) and FeNO. Materials and Methods: This was a cross-sectional study on 879 adult subjects participating in the Shahedieh Cohort Study. BMI and FeNO were measured for each participant. Participants were divided into five BMI groups: underweight, normal, overweight, obese, and morbid obese FeNo level was compared between groups. The data were analyzed by SPSS (ver. 20) using Kolmogorov-Smirnov, Kruskal-Wallis, Mann-Whitney U tests, Spearman's correlation, and multivariate logistic regression tests. Results: The mean FeNO in all participants was 7.87±8.28 ppb. There was a significant positive correlation between age and FeNO. FeNO was declined by increasing BMI, so the highest FeNO was observed in underweight and the lowest FeNO was observed in morbid obese individuals. However, there was not a significant difference in FeNO level between different BMI categories (P =0.28). The mean FeNO level was significantly correlated to BMI only in participants younger than 48 years. Conclusion: The results of this study showed that BMI is probably negatively correlated with FeNO level in middle-aged people younger than 48 years, but not in older people.

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Airway inflammationBMIFeNOObesityPersian Cohort

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PMID40704353

PMCPMC12281338

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