Relationship between Severity of Chronic Obstructive Pulmonary Disease and Left Ventricular Diastolic Dysfunction.

Somayeh Lookzadeh, Seyyed Reza Seyyedi, Hamidreza Jamaati, Fatemehalsadat Miraboutalebi, Mahsa Rekabi

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In one paragraph

Article in Tanaffos, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Somayeh LookzadehChronic Respiratory Disease Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Seyyed Reza SeyyediLung transplantation Research center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Hamidreza JamaatiChronic Respiratory Disease Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Fatemehalsadat MiraboutalebiChronic Respiratory Disease Research Center, National Research Institute of Tuberculosis and Lung Disease (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Mahsa RekabiPediatric Respiratory Diseases Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is an inflammatory systemic disorder that affects the respiratory tract airways and breathing. Left ventricular diastolic dysfunction (LVDD), which is the inability of the ventricle to fill to a normal end-diastolic volume, may be observed in patients with severe COPD. This study aimed to evaluate LVDD in patients with COPD. Materials and Methods: This cross-sectional study included 58 patients under 65 years of age with COPD as the case group. Moreover, 58 patients with normal spirometry and without pulmonary or cardiac disease were included as the control group. They referred to the cardiologist for echocardiography. Patients were tested for C-reactive protein (CRP) and N-terminal pro-B-type natriuretic peptides (NT -pro BNP). Data were analyzed with SPSS for descriptive reports of the relationship between variables. Results: The results showed that LVDD was significantly higher in COPD patients (60%) than in the control group (12.2%). Also, there was no significant relationship between LVDD and BMI in COPD patients. Evaluation of CRP and PRO-BNP showed that the distribution of patients in different diastolic function classes is similar. It was observed that with increasing COPD severity, LVDD severity increased (p-value =0.101). There is a direct relationship between total lung capacity (TLC) and LVDD (P-value <0.0001). In COPD patients, there was a significant relationship between diastolic function and SPAP (P-value <0.0019). Conclusion: In general, it should be noted that the prevalence of LVDD in patients with COPD is significantly higher than in other people.

Indexed as

Cardiovascular complicationsChronic obstructive pulmonary diseaseLeft ventricular diastolic dysfunctionTotal lung capacity

Identifiers

PMID40704342

PMCPMC12281349

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.