ArticleFrontiers in nutrition2025
Hepatic fat and dietary intake as determinants of metabolic health in obese adolescents: a cross-sectional MRI study.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06032312 (Phenotyping Metabolically Healthy Obese Adolescents), which is not on this map. Not yet cited in PubMed.
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Phenotyping Metabolically Healthy Obese Adolescents
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10 authors.
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Abstract
Background: Obesity in youth is highly associated with metabolic risk. However, a subset of individuals maintains metabolic health despite the presence of obesity. This study aims to identify key factors associated with a metabolically healthy obese (MHO) in adolescents. Methods: This cross-sectional study included 31 adolescents with obesity [median age: 14 y, median body mass index (BMI) Z-score: 2.58] categorized as MHO or metabolically unhealthy obese (MUO) based on the presence of one or more metabolic syndrome criteria. A comprehensive evaluation included MRI assessments of abdominal adipose tissue distribution and hepatic fat content (HFC), physiological and metabolic assessment, serum biomarkers, prenatal and sociodemographic characteristics, and dietary habits. Results: Compared to the MUO, MHO individuals exhibited significantly lower HFC ( Conclusion: Adolescents with MHO show lower hepatic fat, improved liver markers, and healthier dietary patterns than MUO peers. These findings underscore the potential influence of prenatal and lifestyle factors in distinguishing metabolic health profiles in adolescents with obesity. Clinical trial registration: https://clinicaltrails.gov/study/NCT06032312; NCT06032312.
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