ArticleFrontiers in physiology2025
Development of thin-film micro-outlets for spatially constraining local PO
Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To develop and validate thin-film micro-outlet devices to study microvascular blood flow responses to localized changes in skeletal muscle oxygen concentration ([O Methods: 30 male Sprague-Dawley rats (159-194 g) were anesthetized and instrumented to maintain cardiovascular state. The extensor digitorum longus (EDL) muscle was dissected, isolated, and reflected over a gas exchange chamber (GEC) mounted in the stage of an inverted microscope. The GEC and EDL were coupled via a composite, gas permeable membrane, and a gas impermeable film fabricated with laser machined micro-outlets of specific diameters (200, 400, 600, and 1,000 μm). [O Results: [O Conclusion: Our composite thin-film devices were fabricated and validated to spatially confine oxygen perturbations to capillaries using micro-outlets of varying diameters. These results demonstrate that our devices can manipulate capillary SO
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