ReviewFrontiers in endocrinology2025
From molecular mechanism to plant intervention: the bidirectional regulation of inflammation and oxidative stress in bone aging.
Review in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Retinal biological age correlates with bone mineral density and fracture risk score and predicts incident osteoporosis.PLOS digital health · 2026Article
- Explainable machine learning for osteoporosis detection in patients with osteopenia: model development and validation using routine clinical data from an Asian cohort.Frontiers in endocrinology · 2026Article
- The role and mechanisms of bone microenvironment regulators in osteoporosis: novel intervention strategies for addressing the challenges of aging.Frontiers in endocrinology · 2026Review
- From molecular mechanisms to translational applications: a parallel assessment of green and black tea modulation of oxidative stress.Nutrition & metabolism · 2025Review
- Modulating M1/M2 macrophage polarization with plant metabolites: a therapeutic strategy for rheumatoid arthritis.Frontiers in pharmacology · 2025Review
Corrections and comments
- Retraction · 2026-01-28Compromised Peer Review · Investigation by Journal/Publisher ·
- Retracted
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article systematically elaborates the central role of inflammatory response and oxidative stress in osteoporosis (OP) and cartilage injury, and reveals the molecular mechanism by which the two damage bone homeostasis through NF-κB, RANKL and other signaling pathways. Studies have shown that plant natural products (such as hesperidin, curcumin, Epimedin B, etc.) can improve bone metabolism imbalance and delay the process of bone aging by regulating inflammatory factors (TNF-α, IL-1β) and antioxidant pathways (Nrf2/HO-1). Osteoporosis and cartilage damage promote each other to form a vicious cycle, and the intervention of plant active ingredients can target this common pathological process. Based on the current evidence, the strategy of combining anti-inflammation, anti-oxidation and mechanical regulation may provide a new direction for the prevention and treatment of bone aging-related diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.