ArticleEnvironment & health (Washington, D.C.)2025
Serial Cross-Sectional Human Biomonitoring Analysis of Pesticide Exposure Patterns and Their Association with Lipid Metabolism Biomarkers: The Mediating Role of Liver Function.
Article in Environment & health (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Uncovering Analytical Patterns for Hazardous Components in Agricultural Production Systems.Foods (Basel, Switzerland) · 2025Review
- Pesticide and Liver Biomarkers Among Ecuadorian Adolescents and Adults Living in Agricultural Settings.Toxics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Continuous low-level exposure to pesticides is inevitable in daily life. Previous studies have demonstrated the adverse effects of pesticide exposure on lipid metabolism. However, population studies have focused primarily on individual pesticides and have short-term fluctuations, and the animal experiments used doses far higher than those exposed by the general population. In this study, urinary concentrations of metabolites of three classes of pesticides, including organophosphate, pyrethroid, and phenoxy carboxylic acid, were determined in 1858 participants of repeated cross-sectional biomonitoring programs from 2018 to 2022. We comprehensively analyzed the association of pesticide metabolites and pesticide exposure patterns with lipid metabolism biomarkers. The indirect effects of liver function markers in these associations were explored by using the structural equation model analysis. Generalized linear models showed that 3,5,6-trichloro-2-pyridinol and para-nitrophenol were positively correlated with high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglyceride. In contrast, 3-phenoxybenzoic acid was negatively correlated with apolipoprotein B. Quantile g-computation and Bayesian Kernel Machine Regression showed a consistent gradual increase in high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels but a gradual decrease in apolipoprotein B levels with increasing exposure to pesticide mixtures. By analyzing the exposure patterns of different categories of pesticides, we found that the population has a high level of exposure to organophosphate pesticides, which disrupts lipid metabolism more significantly than other pesticides. Liver function exhibited significant mediating effects in the association between pesticide exposure and lipid metabolism biomarkers. The results indicated that pesticide exposure was significantly associated with lipid metabolism, and this association may be modulated by improvements in liver function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.