Evidence map›Paper›PMID 40704016›Full record

ArticleMaterials today. Bio2025

Breaking the siege of hypoxia and lactate: carrier-free flexible dual-enzyme protein vesicle to ignite photodynamic-immune storm in head and neck squamous cell carcinoma.

Yan Zhou, Xiaoquan Xu, Ziyue Zu, Shangyu Lu, Wei Lu, Xi Luo, Nan Zhong, Yang Liu, Zhaogang Teng, Shouju Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yan ZhouLaboratory of Molecular Imaging, Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, PR China.
Xiaoquan XuLaboratory of Molecular Imaging, Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, PR China.
Ziyue ZuLaboratory of Molecular Imaging, Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, PR China.
Shangyu LuLaboratory of Molecular Imaging, Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, PR China.
Wei LuKey Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials, Jiangsu National Synergetic Innovation Centre for Advanced Materials, Nanjing University of Posts and Telecommunications, PR China.
Xi LuoLaboratory of Molecular Imaging, Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, PR China.
Nan ZhongLaboratory of Molecular Imaging, Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, PR China.
Yang LiuLaboratory of Molecular Imaging, Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, PR China.
Zhaogang TengKey Laboratory for Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials, Jiangsu National Synergetic Innovation Centre for Advanced Materials, Nanjing University of Posts and Telecommunications, PR China.
Shouju WangLaboratory of Molecular Imaging, Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, PR China.
Feiyun WuLaboratory of Molecular Imaging, Department of Radiology, The First Affiliated Hospital with Nanjing Medical University, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodynamic therapy (PDT) efficacy in head and neck squamous cell carcinoma (HNSCC) is hindered by hypoxia and lactate accumulation in tumor microenvironment (TME), which suppress reactive oxygen species (ROS) generation and immune activation. To address this, we developed a carrier-free flexible dual-enzyme protein vesicle by covalently conjugating human serum albumin (HSA), catalase (CAT), and lactate oxidase (LOX) onto a mesoporous silica template, followed by template etching. Subsequently, the near-infrared photosensitizer IR808 was incorporated to obtain the final nanoparticle (HSA/CAT/LOX@IR808). This system employs a self-sustaining enzymatic cascade: CAT alleviates hypoxia by converting tumor-derived H

Indexed as

Head and neck squamous cell carcinomaHypoxiaLactic acidPhotodynamic therapyProtein vesicle

Identifiers

PMID40704016
PMCPMC12284486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.