Evidence map›Paper›PMID 40704012›Full record

ReviewMaterials today. Bio2025

Engineering principles of zwitterionic hydrogels: Molecular architecture to manufacturing innovations for advanced healthcare materials.

Hoang Linh Bui, Hoang Nam Nguyen, Jui-Yang Lai, Chun-Jen Huang

Abstract readReview
In one paragraph

Review in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hoang Linh BuiFaculty of Biotechnology, Chemistry, and Environmental Engineering, PHENIKAA School of Engineering, PHENIKAA University, Hanoi, 12116, Viet Nam.
Hoang Nam NguyenFaculty of Automation Engineering, Can Tho University, 3/2 Street, Can Tho city, 900000, Viet Nam.
Jui-Yang LaiDepartment of Biomedical Engineering, Chang Gung University, Taoyuan City, 33302, Taiwan, ROC.
Chun-Jen HuangDepartment of Chemical and Materials Engineering, National Central University, Chungli County, Taoyuan City, 32049, Taiwan, ROC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zwitterionic hydrogels have garnered significant attention for their exceptional anti-fouling properties and biocompatibility. These materials have been further enhanced through the incorporation of highly crosslinked 3D networks, endowing them with novel physicochemical characteristics such as stimuli-responsive swelling, ion conductivity, and antibacterial capabilities. In certain cases, zwitterionic motifs can impart self-healing properties for hydrogels, potentially paving the way for the development of functional biomaterials that closely mimic biological tissues. In recent years, we have witnessed substantial efforts from the scientific community to harness the potential of zwitterionic hydrogels for various biomedical applications. This review offers a comprehensive examination of the design principles underlying these materials, spanning from molecular engineering aspects to recent advancements in synthesis routes and fabrication methods. The discussion encompasses the advantages and limitations of different preparation processes, as well as prospects for zwitterionic hydrogels. As a result, this review aims to provide valuable insights for researchers and engineers working to optimize zwitterionic hydrogels for specific biomedical applications, including drug delivery, tissue engineering, and biosensors.

Indexed as

Biomedical applicationsHydrogelMolecular designPreparation processZwitterionic

Identifiers

PMID40704012
PMCPMC12284511

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.