Evidence map›Paper›PMID 40703959›Full record

ArticleIDCases2025

Herpetic gingivostomatitis mimicking Stevens-Johnson syndrome in an immunosuppressed adolescent with idiopathic chorioretinitis.

Aim-On Saengsirinavin, Chaw-Ning Lee, Negin Yavari, Frances Andrea Anover, Zheng Xian Thng, Jia-Horung Hung, Chew Zhi Rui John, Dalia El Feky, Osama Elaraby, Xiaoyan Zhang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IDCases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Aim-On SaengsirinavinByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Chaw-Ning LeeDepartment of Dermatology, Stanford University, Palo Alto, CA, USA.
Negin YavariByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Frances Andrea AnoverByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Zheng Xian ThngByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Jia-Horung HungByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Chew Zhi Rui JohnNational University of Singapore, Yong Loo Lin School of Medicine, Singapore.
Dalia El FekyByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Osama ElarabyByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Xiaoyan ZhangByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Cigdem YasarByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Azadeh MobasserianByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Amir AkhavanrezayatByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Ngoc Trong Tuong ThanByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Christopher OrByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.
Quan Dong NguyenByers Eye Institute, Department of Ophthalmology, Stanford University, Palo Alto, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present the case of an 18-year-old male with bilateral idiopathic chorioretinitis maintained on immunosuppressive therapy with prednisone, adalimumab, and mycophenolate mofetil, who developed ulcers and bleeding of the lip mucosa after taking nonsteroidal anti-inflammatory drugs (NSAIDs) and amoxicillin/clavulanate for a suspected ear infection. The clinical presentation initially mimicked Stevens-Johnson syndrome (SJS), but further evaluation confirmed the diagnosis of herpetic gingivostomatitis. This case highlights the diagnostic challenges in differentiating between drug eruptions and infectious etiologies in immunosuppressed patients. Despite its severity, prompt recognition and antiviral therapy can lead to full recovery.

Indexed as

AdalimumabHerpetic gingivostomatitisHSV-1Mycophenolate mofetilStevens-Johnson syndrome

Identifiers

PMID40703959
PMCPMC12283547

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.