Effect of Ciprofol on Postoperative Delirium in Elderly Patients Undergoing Hip Surgery: A Randomized Controlled Trial.

Purpose: As a novel intravenous anaesthetic, ciprofol is widely used in clinical practice. However, its potential association with postoperative delirium (POD) is unclear. Silent information regulator factor 3(SIRT3) could regulate mitochondrial function, initiate mitochondrial autophagy, and has played an important role in maintaining normal neuronal cell function. This trial aimed to explore the effect of ciprofol on the pathogenesis of POD and whether SIRT3 had a correlation with the pathogenesis of POD. Patients and methods: One hundred fourteen elderly patients scheduled for elective hip joint surgery were included in this randomized controlled, double blind study. The patients were randomly assigned at a 1:1 ratio to either the ciprofol group (Group C, induction of anaesthesia with 0.3 mg/kg ciprofol) or the propofol group (Group P, induction of anaesthesia with 1.5 mg/kg propofol). On postoperative days 1 and 3, the 3D-CAM scale was used to assess whether POD occurred in both groups of patients. Results: No statistically significant difference was observed in the general condition of the patients in the two groups. Within the first 3 days after surgery, the incidence of POD was lower in Group C than in Group P (5.5% vs 20%; Conclusion: In this study, we found that ciprofol was associated with a lower incidence of POD and had a minimal impact on circulatory function. SIRT3 expression and POD were correlated. A serum SIRT3 level less than 1.565 ng/mL on postoperative day 1 may indicate a likelihood of POD, highlighting its potential diagnostic value.