Evidence map›Paper›PMID 40703849›Full record

ArticleClinical neurophysiology practice2025

Comparative analysis of signal quality and usability for a novel wireless, wearable EEG sensor.

Vamshi K Muvvala, Avidor B Kazen, Tyler J Newton, Zoë Tosi, Michael Elwood, Mark J Lehmkuhle, Tobias Loddenkemper, Mark C Spitz, Laura Strom, Daniel Friedman and 1 more

Abstract read
In one paragraph

Article in Clinical neurophysiology practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Vamshi K MuvvalaEpitel, Inc., Salt Lake City, UT, United States.
Avidor B KazenEpitel, Inc., Salt Lake City, UT, United States.
Tyler J NewtonEpitel, Inc., Salt Lake City, UT, United States.
Zoë TosiEpitel, Inc., Salt Lake City, UT, United States.
Michael ElwoodEpitel, Inc., Salt Lake City, UT, United States.
Mark J LehmkuhleEpitel, Inc., Salt Lake City, UT, United States.
Tobias LoddenkemperDivision of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital & Harvard Medical School, Boston, MA, United States.
Mark C SpitzEpilepsy Section, Department of Neurology, University of Colorado, Aurora, CO, United States.
Laura StromEpilepsy Section, Department of Neurology, University of Colorado, Aurora, CO, United States.
Daniel FriedmanDepartment of Neurology, NYU Grossman School of Medicine, NYU Langone Health, New York City, NY, United States.
Mitchell A FrankelEpitel, Inc., Salt Lake City, UT, United States.

Funding

Automated Seizure Detection for Home Seizure Monitoring with Epilog SensorsU44NS121562 · NINDS · EPITEL, INC. · PI LEHMKUHLE, MARK J. · 2021 to 2025
$6.3M
EEG PatchR44NS100235 · NINDS · EPITEL, INC. · PI LEHMKUHLE, MARK J. · 2017 to 2019
$2.1M
EEG PatchR43NS100235 · NINDS · EPITEL, INC. · PI LEHMKUHLE, MARK J. · 2016 to 2016
$231k
NINDS NIH HHS R43 NS100235NINDS NIH HHS R44 NS100235NINDS NIH HHS U44 NS121562
6 · The paper itself

Abstract

Objective: This study details the design, efficacy, and usability of a novel wearable, wireless electroencephalography (EEG) sensor designed for extended-duration clinical monitoring in any environment. Methods: Simultaneous EEG recordings from REMI sensors and a conventional scalp-EEG recording system were conducted across two cohorts: 1) participants undergoing routine epilepsy seizure monitoring and 2) healthy volunteers performing tasks to induce common EEG artifacts. Comparative time and spectral-based analyses were conducted between the recording modalities. Sensor usability was also evaluated. Results: The temporal dynamics and signal morphology of artifacts and electrographic seizures were visually similar between the REMI sensor and conventional scalp-EEG. Additionally, spectral correlation between the two systems was high across all event types, ranging from 0.86 to 0.94. Patient-reported acceptance was also strong, with 69% of participants rating the sensors as comfortable to wear. Conclusions: The REMI sensor showed strong agreement with conventional scalp-EEG in the signal characteristics of physiological artifacts and electrographic seizures. The positive comfort feedback further supports the REMI sensors' everyday utility. Significance: Although limited in electrode coverage compared to conventional scalp-EEG recording systems, the REMI sensor records comparable high-fidelity EEG data in both time and spectral domains. REMI sensor's recording quality and wearability facilitate extended-duration monitoring in everyday environments.

Indexed as

AmbulatoryElectroencephalographySeizuresSensorWireless

Identifiers

PMID40703849
PMCPMC12284292

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.