ReviewJournal of oral and maxillofacial pathology : JOMFP
Alkaline phosphatase and acid phosphatase in health and disease - A systematic review.
Review in Journal of oral and maxillofacial pathology : JOMFP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- In vitro evaluation of hydroxyapatite, β-tricalcium phosphate, graphene oxide and zinc oxide for osteochondral regeneration under inflammatory conditions.Molecular and cellular biochemistry · 2026Article
- Bone-specific alkaline phosphatase as a marker of bone formation: Clinical and imaging correlates.World journal of experimental medicine · 2026Review
- Effects of dietary PQQ·NaPoultry science · 2026Article
- Progression to Radiographic Axial Spondyloarthritis: A Narrative Review on Timeline and Novel Prediction Factors.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone growth and remodelling are the outcomes of osteoblastic and osteoclastic cell activity which may be assessed by the biochemical markers. Alkaline phosphatase (ALP) is a hydrolase enzyme associated with osteoblastic activity, and in contrast, acid phosphatase (AP) is associated with osteoclastic activity and is widely used as a prognostic and diagnostic marker for bone-related lesions. This systematic review aims to analyse the applicability of alkaline phosphatase and acid phosphatase as diagnostic and prognostic markers in various pathological conditions. A systematic review was conducted using PRISMA guidelines. Electronic databases such as PubMed and Cochrane were searched for relevant articles with the keywords ALKALINE PHOSPHATASE and ACID PHOSPHATASE from 1990 to 2023. Studies on alkaline phosphatase and acid phosphatase levels in bone lesions and chronic kidney disease were included. After thorough scrutiny, 55 articles fulfilled our inclusion criteria and exclusion criteria. On tabulating the extracted data, 15% of studies stated that pre-operative serum ALP levels differ in fibro-osseous lesions with fibrous dysplasia having the highest level. 11% of studies used a centrifugal autoanalyser and 10% of studies used colorimetry and ELISA for detecting serum ALP. This systematic review reveals the most widely used method of detection of ALP and AP in pathologic situations and also highlights its diagnostic and prognostic significance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.