ArticleResuscitation plus2025
A chain of survival for drug overdose.
Article in Resuscitation plus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Preparing Emergency Medical Services for Prehospital Buprenorphine: Examining a Train-the-Trainer Approach to Strengthening the Overdose Chain of Survival.Journal of the American College of Emergency Physicians open · 2026Article
- Developing Longitudinal Post-Overdose Care: A Call to Action.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2026Article
- Medical Toxicology is the Overdose Specialty: Implications for the Dimensions and Continuum of Overdose Care.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2026Article
- Is the overdose chain of survival the missing link in reducing overdose deaths globally?Resuscitation plus · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drug overdose is a leading global cause of preventable morbidity and mortality and is closely associated with out-of-hospital cardiac arrest. While the American Heart Association's "chain of survival" has improved outcomes in traditional cardiac arrest, it does not address the unique characteristics and challenges of overdose-related emergencies. In this article, we propose a novel "overdose chain of survival" to emphasize the importance of linking acute care with long-term prevention. This six-link framework includes: (1) prevention, (2) recognition and activation of emergency services, (3) basic first aid, (4) emergency treatment, (5) post-overdose care, and (6) recovery and secondary prevention. Each link highlights opportunities for intervention and coordination across systems of care. The framework is intended to guide clinical care, policy development, education, and research. By viewing overdose through a structured and holistic lens, the overdose chain of survival seeks to improve outcomes in the immediate aftermath of an overdose and also to address systemic barriers to sustained recovery. This conceptual model is adaptable to evolving drug trends and highlights the need for integrated, patient-centered approaches to overdose response and prevention.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.