ArticleNeuro-oncology advances
Proteins of the cancer cell secretome induce the protumoral microenvironment of diffuse intrinsic pontine glioma.
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Immunosuppressive roles of pericytes in cancer disease: insights from a systematic review and meta-analysis.Journal of translational medicine · 2026Pooled it
- CNS distribution and preclinical activity of the PI3K/AKT inhibitors inavolisib and ipatasertib in pediatric-type diffuse high-grade gliomas.Cancer chemotherapy and pharmacology · 2026Article
- MALDI-TOF Mass Spectrometry for Glioblastoma Secretome Biomarker Screening: A Review of Challenges and Perspectives.Current issues in molecular biology · 2026Review
- Consequences of irradiation on blood-brain tumor barrier model of Diffuse Midline Glioma: characterization of physical and metabolic properties.Fluids and barriers of the CNS · 2026Article
Corrections and comments
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Authors and funding
18 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The microenvironment of diffuse intrinsic pontine glioma (DIPG) is devoid of infiltrating lymphocytes and immune checkpoint molecules, with the exception of B7-H3. Here, we studied whether the cancer secretome is a determinant of such tumor phenotype. Methods: We quantified immune histologic markers in paraffin-embedded DIPG samples and healthy brainstem controls. We identified and quantified cytokines in frozen tissue samples, DIPG culture supernatants, cerebrospinal fluid (CSF) and plasma from patients and controls. We studied the phenotype of mesenchymal cells, brain microvascular endothelial cells and macrophages following their exposure to DIPG secretomes. Results: We found profuse infiltration of anti-inflammatory CD163 Conclusions: DIPG cells secrete proteins that create an immunosuppressed niche.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.