ArticleNeuropsychiatric disease and treatment2025
The Association of Glycemic Gap with Cognitive Function After Ischemic Stroke or Transient Ischemic Attack.
Article in Neuropsychiatric disease and treatment, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- The Glycaemic Gap is not a Reliable Prognostic Biomarker for Predicting Post-Stroke Cognitive Impairment [Letter].Neuropsychiatric disease and treatment · 2025Article
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4 authors.
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Abstract
Background: Glycemic gap (GG), as a measure of an acute derangement in glucose level in response to an active disease state, has been found to be associated with adverse outcomes in many diseases. This study aimed to determine the relationship of GG with cognitive function after ischemic stroke or transient ischemic attack (TIA). Methods: Patients included were enrolled from a subgroup of China National Stroke Registry-III (CNSR-III). Cognitive function was assessed by the Beijing edition of the Montreal cognitive assessment (MoCA) scale. Post-stroke cognitive impairment (PSCI) was diagnosed as a MoCA score≤22. Post-stroke cognitive decline (PSCD) was defined as a decrease of >2 points on the MoCA score between the 3-month and 1-year assessments. GG was calculated using admission blood glucose minus hemoglobin A1c-derived average blood glucose. Multivariable logistic regression analysis was used to evaluate the correlation between GG and cognitive function. Results: We enrolled 767 patients with a median age of 60 years old, including 247 (32.2%) patients with PSCI in 3 months, 228 (29.73%) with PSCI in 1 year, and 166 (21.64%) patients with PSCD. The highest GG levels were related to PSCI in 3 months after adjusted for multiple potential confounders (adjusted odd ratio (OR): 2.021, 95% CI: 1.055-3.869, Conclusion: Our findings show that GG is associated with acute post-stroke cognitive impairment, but not with the long-term cognitive impairment or cognitive decline.
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