ArticleFrontiers in neurology2025
Glymphatic dysfunction assessed by DTI-ALPS index predicts early cognitive impairment in acute subcortical infarcts: a prospective clinical cohort study.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical and preclinical evidence of meningeal immunity and glymphatic pathways in stroke: a systematic review.Frontiers in immunology · 2026Pooled it
- Physical exercise as a non-pharmacological strategy to enhance glymphatic function.IBRO neuroscience reports · 2026Review
- Bi-component modeling of cerebrospinal fluid outflow using Time-SLIP MRI.Fluids and barriers of the CNS · 2026Article
- Post-stroke glymphatic and meningeal lymphatic dysfunction: mechanisms, imaging evidence, and translational challenges.Frontiers in stroke · 2026Review
- Glymphatic system dysfunction associated with player position in collegiate American football players: A DTI-ALPS study.Neuroimage. Reports · 2025Article
- Diffusion Tensor Imaging Along the Perivascular Space (DTI-ALPS) in Ischemic Stroke: A Systematic Review of Diagnostic and Prognostic Performance for Post-Stroke Cognitive Impairment.Diagnostics (Basel, Switzerland) · 2025Review
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Authors and funding
9 authors.
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Abstract
Background: The glymphatic system (GS), responsible for clearing neurotoxic proteins (such as β-amyloid and tau protein), is critical in stroke pathophysiology. However, its role in acute post-stroke cognitive impairment (PSCI) remains unclear. We investigated GS dysfunction via the DTI-ALPS index in acute subcortical infarct patients and its association with early cognitive decline. Methods: This prospective cohort included 29 subcortical infarct patients and 25 healthy controls (HC). Participants underwent 3.0 T MRI (DTI/structural sequences) and Montreal Cognitive Assessment (MoCA) at 7 and 90 days post-stroke. Bilateral DTI-ALPS indices were calculated. Group comparisons and Spearman correlations were analyzed. Results: The DTI-ALPS index of the lesion (1.371 ± 0.170) and non-lesion side (1.310 ± 0.198) in the SI group were significantly lower than that in HC group (1.568 ± 0.115) (both of Conclusion: Ischemic stroke leads to glymphatic dysfunction, which is associated with early post-stroke cognitive impairment.
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