ArticleFrontiers in neurology2025
Association between white matter hyperintensities and gray matter volume in cerebral small vessel disease: insights from periventricular and deep white matter lesions.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the relationship between the severity of periventricular white matter hyperintensities (PWMH) and deep white matter hyperintensities (DWMH) and gray matter volume in cerebral small vessel disease (CSVD) patients. Methods: Clinical and imaging data from 125 CSVD patients, collected between April and December 2022, were analyzed. The severity of PWMH and DWMH was assessed using the Fazekas scale. 3D T1-weighted images were processed with FSL software to segment gray matter and intracranial volume. The normalized gray matter volume (GM_n) was computed as the proportional ratio of gray matter volume relative to total intracranial volume. Results: Group-level analysis revealed significant differences in GM_n were observed across various Fazekas scores for both DWMH ( Conclusion: PWMH, but not DWMH, is independently associated with gray matter volume and partially mediates the age-related decline in GM volume. These findings highlight the topographical and mechanistic heterogeneity of WMH subtypes and underscore PWMH as a potential imaging marker for early intervention in CSVD-related neurodegeneration.
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