ArticleIranian journal of basic medical sciences2025
Spermine: A prospective treatment for high glucose-induced myocardial fibrosis in db/db mice.
Article in Iranian journal of basic medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: This study explored the molecular mechanism by which exogenous spermine attenuates diabetic cardiomyopathy (DCM)-induced myocardial fibrosis. Materials and Methods: db/db mice and primary neonatal mouse cardiac fibroblasts were used to conduct Results: After 12 weeks, the mice in the type 2 diabetes (T2D) group exhibited increased blood glucose, TG, TC, and serum myocardial marker enzyme levels. Ejection fraction (EF) and left ventricular fractional shortening left ventricular fractional shortening (FS) decreased, while LVIDs and LVIDd increased. Significant collagen fiber deposition and increased HW/TL ratio, SSAT, α-SMA, TGF-β1, and Collagen-I/III expression was observed in myocardial tissue. Conversely, ODC expression was down-regulated. In the T2D + spermine (SP) group, these trends were reversed. Conclusion: Our findings demonstrate that SP reduces collagen synthesis and secretion by inhibiting the TGF-β1/Smads signaling pathway. These results provide new insights into potential therapeutic approaches for DCM.
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