ReviewIranian journal of basic medical sciences2025
The neuroprotective effects of hesperidin and diosmin in neurological disorders via targeting various signaling pathways.
Review in Iranian journal of basic medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Machine Learning-Integrated Pharmacophore, DFT Analysis, and molecular dynamics of Diosmetin as a potent ache inhibitor with neuroprotective activity in a Scopolamine-Induced alzheimer's zebrafish model.Journal of computer-aided molecular design · 2026Article
- Citrus flavonoids mitigate the cisplatin-induced ovarian toxicity via dual modulation of Nrf2/HO-1 pathway and NF-κB axis.Frontiers in pharmacology · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diosmin and hesperidin, two flavonoid glycosides derived from citrus plants, offer numerous health benefits, whether used alone or in combination. They can mitigate neurodegenerative symptoms and reduce vascular and microbial inflammations, improving cardiovascular health and modulating immunity and anti-oxidant properties. Neuroinflammation and oxidative stress are associated with numerous neurological disorders. This study aims to review the neuroprotective potentials of diosmin and hesperidin, focusing on their effects on oxidative stress and inflammatory conditions. A scientific literature search was conducted using specific keywords in various databases, including PubMed, Web of Science, Google Scholar, Embase, and Scopus.Diosmin and hesperidin demonstrated protective effects in managing a variety of neurological disorders, such as epilepsy, neuropathy, depression, anxiety, insomnia, autism, glioblastoma, traumatic brain injury, cerebral ischemia-reperfusion, Huntington's disease, Alzheimer's disease, Parkinson's disease, neurotoxicity, and multiple sclerosis through the regulation of various signaling pathways. Hesperidin and diosmin exhibit promising neuroprotective effects that underscore their potential as natural multi-targeted therapeutic agents for treating neurological disorders through diverse cascades.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.