ArticleFrontiers in aging neuroscience2025
Differential methylation of
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Epigenetic regulators polyphenols in neurodegenerative diseases: a promising intervention strategy.Annals of medicine · 2026Review
- Neurobiology of exercise in Parkinson's disease.Journal of Parkinson's disease · 2026Review
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor symptoms such as bradykinesia, rigidity, and tremor. Despite its prevalence, genetic and epigenetic studies in the Mexican Mestizo population (individuals of mixed Indigenous and European-primarily Spanish-ancestry who represent the majority demographic in Mexico) remain limited. DNA methylation may play a role in PD pathogenesis, with peripheral blood methylation patterns serving as potential biomarkers. This study examines Methods: In this case-control study, we enrolled 108 PD patients and 108 age- and sex matched controls from Mexico City and Durango. Genomic DNA was extracted from leukocytes, and bisulfite pyrosequencing was performed to assess methylation levels at specific CpG sites within Results: Our analysis revealed a significant reduction in global methylation levels in the Conclusion: Our findings reveal significant
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.