ArticleFrontiers in cellular and infection microbiology2025
Gut microbiota changes in postmenopausal women with low bone density linked to serum amino acid metabolism.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Bacterial small RNAs and extracellular vesicles in inflammatory and osteoimmune diseases: regulatory mechanisms and host-microbe communication.Archives of microbiology · 2026Review
- Research Progress on Mechanisms of Milk-Derived Functional Components in Regulating Bone Health and the Gut-Bone Axis.Nutrients · 2026Review
- Article
- Impact of microbiome alterations on fracture healing and nonunion: a narrative review.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2026Review
- Causal association between gut microbiota and osteonecrosis in European populations: a two-sample Mendelian randomization analysis.Journal of bone and mineral metabolism · 2026Article
- Aging-Driven Inter-Organ Crosstalk in Postmenopausal Osteoporosis: From Immunometabolic Drift to Multisystem Frailty.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The gut microbiota (GM) has been linked to changes in bone mineral density (BMD), potentially contributing to the development of osteopenia or osteoporosis. Although the relationship between specific bacterial taxa and bone remodeling has been documented in various populations, data on the Mexican population remain limited. This study aimed to analyze the changes in the taxonomic composition of GM associated with low BMD (osteopenia/osteoporosis) and explore potential mechanisms influencing bone metabolism in Mexican postmenopausal women. Methods: BMD was measured by dual-energy X-ray absorptiometry. GM composition was analyzed through 16S rRNA amplicon sequencing in Mexican postmenopausal women. Metabolic functions were predicted using PICRUSt2 based on KEGG pathways at hierarchy level 3. Serum amino acid (AA) concentrations were measured in a sub-sample using tandem mass spectrometry. Results: Our findings indicated that beta diversity significantly differed among BMD groups (p<0.05). Women with low BMD showed higher relative abundances of Conclusion: This study provides evidence of the relationship between GM composition and AA concentrations with changes in BMD. These findings highlight promising areas for the development of potential therapeutic interventions.
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