ReviewFrontiers in cell and developmental biology2025
Schwann cell reprogramming via EMT-like program following peripheral nerve injury and during nerve regeneration.
Review in Frontiers in cell and developmental biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Article
- Wallerian Degeneration and Nerve Regeneration-A Review of Cellular and Molecular Events.International journal of molecular sciences · 2026Review
- Contemporary Strategies of Gene and Cell Therapy in the Treatment of Peripheral Nervous System Injuries and Disorders.International journal of molecular sciences · 2026Review
- Plasticity, injury-induced reprogramming, and translational applications of Schwann cells in neural regeneration.Frontiers in cellular neuroscience · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The activation of the epithelial-mesenchymal transition (EMT) enhances cell plasticity and plays a pivotal role in driving critical biological processes such as embryonic process, tissue repair, and cancer metastasis. EMT is regulated by multiple signaling pathways, including transforming growth factor-β (TGF-β), Wnt, and Notch signaling, and is finely orchestrated by a network of transcriptional factors, epigenetic modifications (such as DNA methylation and histone alterations), and non-coding RNAs. In the peripheral nervous system, Schwann cells undergo a distinct EMT-like transformation following nerve injury, adopting a repair phenotype known as repair Schwann cells. These repair Schwann cells play a multifaceted role in nerve regeneration by clearing myelin debris, secreting regeneration-promoting factors, mediating structural reorganization, and creating a conducive microenvironment for axonal regrowth. Therapeutic strategies targeting the regulation of the EMT-like program of Schwann cells thus hold significant promise for the treatment of peripheral nerve injury, particularly in cases of severe nerve injury with incomplete recovery and poor functional restoration.
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Registered trials
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