ArticleFood science & nutrition2025
Effect of Marine-Derived Scallop Peptide Hydrolysate on Immune Modulation and Gut Microbiota Restoration in Cyclophosphamide-Induced Immunosuppressed Mice.
Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Immunomodulatory effects of Yang He decoction on cyclophosphamide-induced immunosuppression in mice: restoration of immune organ integrity and cytokine balance.Frontiers in pharmacology · 2026Article
- Bio-Active Peptides from Marine Sources: Mechanistic Insights into Immune Regulation, Microbiota Modulation, and Intestinal Barrier Protection.International journal of molecular sciences · 2025Review
- Effect of Marine-Derived Scallop Peptide Hydrolysate on Immune Modulation and Gut Microbiota Restoration in Cyclophosphamide-Induced Immunosuppressed Mice.Food science & nutrition · 2025Article
- Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cyclophosphamide (CTX), a chemotherapy agent, can weaken immune responses and disrupt gut microbiota, resulting in dysbiosis and inflammation. The gut microbiota, a composite community of microorganisms, plays a central role in regulating metabolism, supporting biological functions, and maintaining immune balance. Dysbiosis may lead to various systemic diseases and metabolic issues. This underscores the importance of immunomodulators to boost immune health and restore balance during CTX treatment. This study assessed the impact of scallop peptide hydrolysate (SCH), derived from scallops collected from a local seafood market in Dalian, China, on immune suppression, intestinal integrity, and gut microbiota composition in BALB/c mice with CTX-induced immunosuppression. The findings demonstrated that SCH significantly restored intestinal mucosal integrity of goblet cells, enhanced the levels of tight-junction proteins (Occludens, Zonula-1, Mucin-2, Claudin-1), and improved the histological state of both the colon and spleen. SCH treatment resulted in increased body weight, improved immune organ indices, and enhanced levels of pro-inflammatory cytokines and immunoglobulins, while reducing anti-inflammatory cytokines. Furthermore, SCH exhibited no cytotoxic effects on RAW264.7 macrophages, promoting the formation of pseudopodia and enhancing phagocytic activity, thereby improving cell-mediated immunity and splenic lymphocyte proliferation. Moreover, SCH therapy markedly increased the numbers of CD4
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