SynthesisFrontiers in dental medicine2025
Association between periodontal disease and Alzheimer's disease: umbrella review.
Synthesis in Frontiers in dental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Periodontitis and Tooth Loss Are Associated With Higher Risks of Cognitive Disorders: A Systematic Umbrella Meta-Analysis.Clinical and experimental dental research · 2025Pooled it
- Challenge-based ex vivo immune profiling reveals stimulus-dependent peripheral immune reprogramming in Alzheimer's disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- TLRs and NLRs modulate oral microbiome involvement in Alzheimer's disease.Metabolic brain disease · 2025Review
- The Oral-Brain Axis in Alzheimer's Disease: From Microbial Dysbiosis to Neurodegeneration.Microorganisms · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Alzheimer's disease (AD) and periodontal disease (PD) are both chronic conditions with rising global prevalence. Emerging research suggests a possible link between PD-induced systemic inflammation and neurodegeneration observed in AD. Objective: Employ an umbrella review to look into the association between periodontal disease and Alzheimer's disease. Materials and methods: A comprehensive search was conducted until March 2025 across various electronic databases, including: PubMed, Cochrane Library, Scopus, SciELO, Web of Science, Google Scholar, ProQuest, and OpenGrey, and Dissertations and Theses. There were no time or language restrictions on the inclusion of systematic reviews (SR), with or without meta-analysis, as long as they looked at primary research that connected PD and AD. The following were excluded: preclinical and fundamental research, summaries, comments, case reports, protocols, personal opinions, letters, posters, literary or narrative reviews, fast reviews, intervention studies, and observational studies. The quality and general confidence of the included studies were evaluated using the AMSTAR-2 technique. Results: A total of 358 items were found following the first search. 16 articles were left for additional review after the selection criteria were applied. With odds ratios (OR) and risk ratios (RR) ranging from 1.67 to 2.17 and 1.11 to 2.26, respectively, 14 studies showed a correlation between PD and AD. Conclusions: Drawing from the findings and conclusions of the SR demonstrating a high overall confidence, it's established that PD and tooth loss exhibit an association with AD. Systematic Review Registration: Registered in the Open Science Framework (OSF): DOI 10.17605/OSF.IO/GS367.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.