Evidence map›Paper›PMID 40703546›Full record

ArticleFrontiers in oncology2025

Relationship between DTI-MRI derived metrics and radiotherapy dose range in the contralateral cerebrum in lower grade glioma.

Justyna Kłos, Hildebrand Dijkstra, Hiska L van der Weide, Jan H Potze, Peter F Sinnige, Kelvin Ng Wei Siang, Rudi A J O Dierckx, Ronald J H Borra, Miranda C A Kramer, Anouk van der Hoorn

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Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Justyna KłosDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Hildebrand DijkstraDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Hiska L van der WeideDepartment of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Jan H PotzeDepartment of Radiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Peter F SinnigeDepartment of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Kelvin Ng Wei SiangDepartment of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Rudi A J O DierckxDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Ronald J H BorraDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Miranda C A KramerDepartment of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Anouk van der HoornDepartment of Radiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: To evaluate the value of diffusion tensor imaging (DTI) MRI derived fractional anisotropy (FA) and apparent diffusion coefficient (ADC) for both white matter (WM) and grey matter (GM) of the contralateral cerebrum following radiotherapy (RT) for supratentorial lower grade glioma (LGG) as markers for radiotherapy-induced brain damage (RIBD). Materials and methods: 14 patients were analysed. WM and GM were segmented using automated software (cNeuro) and the mean FA and ADC were extracted per RT dose bin (0-10, 10-20, 20-30, 30-40, 40-50, >50 Gy) of WM and GM. One way ANOVA with Results: We observed changes in FA of WM for dose bin >50 Gy [(F(5, 74) = 5.461, p=0.0002)], but no changes in FA of GM and no changes in ADC for both WM and GM. The percentual change in ADC and FA in WM of dose bin >50 Gy did not correlate with the total volume of FLAIR hyperintensities of the contralateral cerebrum, and also the raw values of these metrics did not correlate within the >50 Gy dose bin, and only correlated with the Total Radiotherapy Dose delivered to the supratentorial brain. Conclusion: In the late phase after RT for LGG (average > 3 years), DTI-MRI derived FA values decreased significantly in WM in the cerebrum contralateral to the tumour, while no changes were observed in GM or in ADC values. The FA decrease is only observed in areas receiving the highest RT dose, allows for a localized assessment in the individual patient, and is not correlated with the observed total load of FLAIR hyperintensities within the contralateral cerebrum or changes in ADC, suggesting DTI-MRI and FLAIR derived metrics reflect RIBD in different ways.

Indexed as

brain damagediffusion tensor imaging (DTI)fluid attenuated inversion recovery (FLAIR)fractional anisotropygliomaradiotherapy

Identifiers

PMID40703546
PMCPMC12283723

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