Evidence map›Paper›PMID 40703540›Full record

ArticleFrontiers in oncology2025

Metastatic mediastinal malignant tumors of gastrointestinal origin with occult primary lesions: a case report.

Yaxuan Liu, Liang Liang Yang, Wen Teng Hu, Rui Jiang Lin, Song la Bai, Min Jie Ma, Biao Han

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yaxuan LiuDepartment of Thoracic Surgery, The First Hospital of Lanzhou University, Lanzhou University, Lanzhou, China.
Liang Liang YangDepartment of Thoracic Surgery, The First Hospital of Lanzhou University, Lanzhou University, Lanzhou, China.
Wen Teng HuDepartment of Thoracic Surgery, The First Hospital of Lanzhou University, Lanzhou University, Lanzhou, China.
Rui Jiang LinDepartment of Thoracic Surgery, The First Hospital of Lanzhou University, Lanzhou University, Lanzhou, China.
Song la BaiDepartment of Thoracic Surgery, The First Hospital of Lanzhou University, Lanzhou University, Lanzhou, China.
Min Jie MaDepartment of Thoracic Surgery, The First Hospital of Lanzhou University, Lanzhou University, Lanzhou, China.
Biao HanDepartment of Thoracic Surgery, The First Hospital of Lanzhou University, Lanzhou University, Lanzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer of unknown primary origin (CUP), accounting for 3-5% of malignancies, poses significant diagnostic challenges because of the absence of identifiable primary lesions. While common occult primary tumors involve the lung or pancreas, gastrointestinal (GI)-originated mediastinal metastases are exceedingly rare. A 54-year-old male presented with chest tightness and dyspnea. Imaging revealed a 45.5 × 36.3 mm anterior mediastinal mass. Pathological evaluation postresection revealed metastatic moderately differentiated adenocarcinoma with immunohistochemical (IHC) features (CK20+/Villin+/CK7-/TTF-1-) suggestive of GI origin. Despite comprehensive evaluations (gastroscopy, PET-CT), no primary lesions were detected. Chronic atrophic gastritis (C2) was noted, but malignancy was excluded. This case underscores the diagnostic complexity of GI-profile mediastinal CUP and highlights limitations in conventional imaging. Molecular profiling (e.g.,

Indexed as

cancer of unknown primarydiagnostic biomarkersgastrointestinal immunophenotypeliquid biopsymediastinal metastasissolitary metastasis

Identifiers

PMID40703540
PMCPMC12284500

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.