Evidence map›Paper›PMID 40703529›Full record

ArticleFrontiers in immunology2025

Successful third haploidentical hematopoietic stem cell transplantation after two graft failures in a pediatric patient with severe aplastic anemia: a case report with five-year follow-up.

Xuewei Li, Wenhui Zhang, Saisai Li, Xiaolin Ma, Xue Shi, Wei Wang, Lingjie Sun, Kuan Qiu, Yanxia Zhao, Chunting Zhao and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

11 authors.

Xuewei LiDepartment of Hematology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.
Wenhui ZhangDepartment of Hematology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.
Saisai LiDepartment of Hematology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.
Xiaolin MaDepartment of Hematology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.
Xue ShiDepartment of Hematology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.
Wei WangDepartment of Hematology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.
Lingjie SunDepartment of Hematology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.
Kuan QiuDepartment of Respiratory and Critical Care Medicine, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.
Yanxia ZhaoDepartment of Hematology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.
Chunting ZhaoDepartment of Hematology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.
Xiaodan LiuDepartment of Hematology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hematopoietic stem cell transplantation (HSCT) offers a potentially curative option for severe aplastic anemia (SAA). However, graft failure (GF) remains a life-threatening complication following HSCT. Haploidentical HSCT may serve as an effective salvage therapy for the treatment of GF. Case presentation: This report describes a 3-year-old girl with acquired SAA who experienced GF twice following matched unrelated donor (MUD) transplantations. Successful engraftment was ultimately achieved through a third haploidentical donor HSCT. This work was conducted in accordance with the Declaration of Helsinki and the Declaration of Istanbul. Conclusions: Based on our experience with this case, we conclude that a third HSCT with a haploidentical donor represents a viable approach to extending survival.

Indexed as

Anemia, AplasticGraft RejectionHematopoietic Stem Cell TransplantationTransplantation, HaploidenticalChild, PreschoolFemaleFollow-Up StudiesHumansTreatment OutcomeUnrelated Donorsconditioning regimensgraft failurehematopoietic stem cell transplantationimmune responsesevere aplastic anemia

Identifiers

PMID40703529
PMCPMC12284796

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