ArticleNeurophotonics2025
Hemodynamic and neuronal contributions to low-frequency vascular oscillations in a preclinical model of Alzheimer's disease.
Article in Neurophotonics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Systems biology analysis of vasodynamics in mouse cerebral arterioles during resting state and functional hyperemia.PLoS computational biology · 2026Article
- Disassociating cerebral vasomotion from low frequency spontaneous neurovascular coupling.Scientific reports · 2025Article
- Noradrenergic Slow Vasomotion: The Hidden Fluid Pump Linking Sleep, Brain Clearance, and Dementia Pathogenesis.International journal of molecular sciences · 2025Review
- Association between low-frequency oscillations in blood pressure variability and brain age derived from neuroimaging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Introduction to the Special Issue "Understanding Brain Disease with Live Imaging".Neurophotonics · 2025Article
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Authors and funding
9 authors.
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Abstract
Significance: Vasomotion, a temporal oscillation in vascular diameter centered around 0.1 Hz, may be altered in Alzheimer's disease (AD), with both increases and decreases reported. Aim: We aimed to better characterize vasomotion Approach: Low-frequency (0.06 to 0.2 Hz) oscillations (LFOs) in the cerebral arteries of anesthetized 9- to 12-month-old J20-AD ( Results: LFOs increased as inspired oxygen was reduced, but the change in LFO power did not differ between groups. LFOs were found to be driven by neuronal activity, suggesting that they represent spontaneous low-frequency neurovascular coupling rather than vascular-only derived activity. Conclusions: Arterial LFOs obtained by 2D-OIS were not a suitable metric to distinguish anesthetized J20-AD males from healthy male controls. Furthermore, hemodynamic oscillations occurring within the same frequency range as vasomotion may reflect underlying neuronal activity.
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