Evidence map›Paper›PMID 40703494›Full record

ArticleRadiology case reports2025

The clinical applications of intrathecal fluorescein in cerebrospinal fluid leak repair.

Hussain J Aljubran, Mohammed F Alzamil, Ali A Alnasser, Mohsen M Bashammakh, Moath A Alfaleh, Ali Almomen

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PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hussain J AljubranCollege of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Mohammed F AlzamilCollege of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Ali A AlnasserCollege of Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.
Mohsen M BashammakhCollege of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Moath A AlfalehDepartment of Otolaryngology Head and Neck Surgery, King Fahad Specialist Hospital, Dammam, Saudi Arabia.
Ali AlmomenDepartment of Otolaryngology Head and Neck Surgery, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebrospinal fluid (CSF) leak is a serious condition that must be diagnosed and managed promptly. The diagnostic approach to this condition involves various radiological modalities, one of which is the application of intrathecal fluorescein (ITF), which has recently gained popularity. However, there are still conflicting results regarding whether ITF is more effective and safer than other radiological modalities in diagnosing CSF leaks. In this study, we present 3 cases with different causes of CSF leaks. The CSF leak was successfully localized and managed in all 3 cases after the administration of 10 mL of CSF mixed with 0.25 mL of 10% fluorescein. In conclusion, ITF appears to be a safe and effective diagnostic modality for identifying CSF leaks. Nonetheless, further studies are needed to compare different doses of ITF in order to establish the optimal formulation and to develop more comprehensive and accurate guidelines for its use.

Indexed as

Cerebrospinal fluid rhinorrheaEndoscopic surgeryIntraoperative complicationsIntrathecal fluoresceinRadiological imaging

Identifiers

PMID40703494
PMCPMC12284674

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.