ArticleiScience2025
Adaptive
Abstract read
In one paragraph
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Understanding physiological adaptations of pregnancy to the chronic hypoxia of high altitude to inform obstetrical and neonatal care.Physiological reviews · 2026Review
- AMPK: Accumulating Evidence in Support of its role in Dual Regulation of Vascular Function and Metabolism During Human Pregnancy.Acta physiologica (Oxford, England) · 2025Review
- Genetic adaptations shaping survival, pregnancy, and life at high altitude and sea level.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Elijah S LawrenceDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology University of California, San Diego, La Jolla, CA, USA.
Wanjun GuDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology University of California, San Diego, La Jolla, CA, USA.
Mitchell C KongDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology University of California, San Diego, La Jolla, CA, USA.
Santiago FassardiDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology University of California, San Diego, La Jolla, CA, USA.
Cecilia Anza-RamirezFisiología del Transporte de Oxígeno y Adaptación a la Altura-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias e Ingeniería, Universidad Perúana Cayetano Heredia, Lima, Peru.
Esteban A MoyaDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology University of California, San Diego, La Jolla, CA, USA.
Erica C HeinrichDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology University of California, San Diego, La Jolla, CA, USA.
James J YuDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology University of California, San Diego, La Jolla, CA, USA.
Jeremy E OrrDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology University of California, San Diego, La Jolla, CA, USA.
Steven Y CaoHerbert Wertheim School of Public Health and Longevity Sciences, University of California, San Diego, La Jolla, CA, USA.
Ana Sanchez-AzofraDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology University of California, San Diego, La Jolla, CA, USA.
Amy M ColeSchool of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
James E HallDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology University of California, San Diego, La Jolla, CA, USA.
Andrew LinDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology University of California, San Diego, La Jolla, CA, USA.
Pamala N DeYoungDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology University of California, San Diego, La Jolla, CA, USA.
Gustavo Vizcardo-GalindoFisiología del Transporte de Oxígeno y Adaptación a la Altura-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias e Ingeniería, Universidad Perúana Cayetano Heredia, Lima, Peru.
Jose-Luis MacarlupuFisiología del Transporte de Oxígeno y Adaptación a la Altura-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias e Ingeniería, Universidad Perúana Cayetano Heredia, Lima, Peru.
Rómulo Figueroa-MujícaFisiología del Transporte de Oxígeno y Adaptación a la Altura-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias e Ingeniería, Universidad Perúana Cayetano Heredia, Lima, Peru.
Daniela BermudezFisiología del Transporte de Oxígeno y Adaptación a la Altura-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias e Ingeniería, Universidad Perúana Cayetano Heredia, Lima, Peru.
Noemi CoranteFisiología del Transporte de Oxígeno y Adaptación a la Altura-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias e Ingeniería, Universidad Perúana Cayetano Heredia, Lima, Peru.
Gianpiero L CavalleriSchool of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.
Eduardo GaioLaboratório de Fisiologia Respiratória, Faculdade de Medicina, Universidade de Brasília, Brasilia, Brazil.
A Mark EvansCentre for Discovery Brain Sciences, Hugh Robson Building, Edinburgh Medical School, University of Edinburgh, Edinburgh, UK.
Frank L PowellDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology University of California, San Diego, La Jolla, CA, USA.
Atul MalhotraDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology University of California, San Diego, La Jolla, CA, USA.
Rany M SalemHerbert Wertheim School of Public Health and Longevity Sciences, University of California, San Diego, La Jolla, CA, USA.
Francisco C VillafuerteFisiología del Transporte de Oxígeno y Adaptación a la Altura-LID, Departamento de Ciencias Biológicas y Fisiológicas, Facultad de Ciencias e Ingeniería, Universidad Perúana Cayetano Heredia, Lima, Peru.
Tatum S SimonsonDepartment of Medicine, Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology University of California, San Diego, La Jolla, CA, USA.
Funding
Medical Scientist Training Program Training GrantT32GM145449 · NIGMS · DUKE UNIVERSITY · PI Christopher D Kontos · 2022 to 2026
$6.6MUC San Diego Genetics Training ProgramT32GM145427 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRUCE A HAMILTON · 2022 to 2026
$2.6MNIGMS NIH HHS T32 GM145427NIGMS NIH HHS T32 GM145449
Abstract
Highland groups have adapted to the extreme selective pressures of hypoxia at high altitude via alterations in the oxygen-transport cascade.
Indexed as
atural sciencesBiological sciencesGeneticsHealth sciencesHuman GeneticsMedical specialtyMedicinePrecision medicine
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.