Evidence map›Paper›PMID 40703438›Full record

ArticleiScience2025

A 3D tumor spheroid model with robust T cell infiltration for evaluating immune cell engagers.

Hin Ching Lo, Hana Choi, Kevin Kolahi, Samantha Rodriguez, Leiru Gonzalez, Felix Chu, Aditee Shrotre, Xi Zhao, Aloma L D'Souza, Ron Ferrando and 1 more

Abstract read
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. DNA-programmed cell assembly: from cells, tissues to organoids.Frontiers in bioengineering and biotechnology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hin Ching LoAbbVie, 1000 Gateway Boulevard, South San Francisco, CA 94080, USA.
Hana ChoiAbbVie, 1000 Gateway Boulevard, South San Francisco, CA 94080, USA.
Kevin KolahiAbbVie, 1000 Gateway Boulevard, South San Francisco, CA 94080, USA.
Samantha RodriguezAbbVie, 1000 Gateway Boulevard, South San Francisco, CA 94080, USA.
Leiru GonzalezAbbVie, 1000 Gateway Boulevard, South San Francisco, CA 94080, USA.
Felix ChuAbbVie, 1000 Gateway Boulevard, South San Francisco, CA 94080, USA.
Aditee ShrotreAbbVie, 1000 Gateway Boulevard, South San Francisco, CA 94080, USA.
Xi ZhaoAbbVie, 1000 Gateway Boulevard, South San Francisco, CA 94080, USA.
Aloma L D'SouzaAbbVie, 1000 Gateway Boulevard, South San Francisco, CA 94080, USA.
Ron FerrandoAbbVie, 1000 Gateway Boulevard, South San Francisco, CA 94080, USA.
Somdutta RoyAbbVie, 1000 Gateway Boulevard, South San Francisco, CA 94080, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A strong interest in drugs targeting the tumor microenvironment (TME) necessitates new experimental systems that incorporate key TME components. Compared to traditional 2D cell lines, 3D

Indexed as

Biological sciencesBiotechnologyNatural sciencesTissue Engineering

Identifiers

PMID40703438
PMCPMC12283745

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.