Evidence map›Paper›PMID 40703416›Full record

ArticleIntegrative medicine (Encinitas, Calif.)2025

Thinking About the Complexity of Food Molecules, Nutrient Activation, and Diverse Biochemical Pathways.

Joseph Pizzorno, Lara Pizzorno

Abstract read
In one paragraph

Article in Integrative medicine (Encinitas, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joseph Pizzorno
Lara Pizzorno

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The physiology of life is complex. The process of understanding its complexity necessarily required simplification and focus on the molecules and biochemical pathways required for life. This focus resulted in huge benefits for understanding life and disease. However, the simplification process itself led to missing or dismissing a lot of important physiology critical for health. The result has been a lack of recognition of many factors important to health, not just life, such as losing many plant molecules when food is grown chemically rather than organically, focusing on major pathways while missing critical secondary pathways, and lacking recognition that single nucleotide variation evolved to adapt to widely diverse food molecules and vitamers. This editorial focuses on the complexity of food molecules, nutrient activation, and biochemical pathways that have thus far lacked recognition, with particular emphasis on the B6 vitamers.

Identifiers

PMID40703416
PMCPMC12282222

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.