ArticleFrontiers in human neuroscience2025
Neuromuscular characteristics of transcranial direct current stimulation over dorsolateral prefrontal cortex in patients with chronic low back pain: a randomized, double-blind, controlled trial protocol.
Article in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Chronic low back pain (cLBP) is a prevalent condition associated with poor rehabilitation outcomes and high recurrence rates. Previous studies suggest that the number, structure, and network patterns of trunk muscle synergy may contribute to this condition. Our previous research mapped the neural representation of cLBP trunk muscles in the primary motor cortex (M1) and identified a disrupted M1-trunk muscle synergy pattern. Recent studies indicate that the dorsolateral prefrontal cortex (DLPFC) has a key role in the internal connectivity of cLBP patients when coping with chronic pain. This study aims to determine whether transcranial direct current stimulation (tDCS) of the DLPFC in cLBP patients can enhance the activity and functional connectivity of M1 and DLPFC, thus improving abnormal trunk muscle synergy. Methods: This study is a randomized, double-blind, controlled trial. Forty-eight individuals aged 20 to 55 years with cLBP will be randomly assigned to receive either (1) a 3-week DLPFC-tDCS intervention ( Discussion: The results of this trial will clarify the efficacy of DLPFC-tDCS in enhancing M1-DLPFC functional connectivity and improving trunk muscle synergy patterns. These findings will provide a theoretical foundation for developing new therapeutic targets for the treatment of cLBP. Clinical trial registration: https://www.chictr.org.cn, identifier ChiCTR2300078887.
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